دورية أكاديمية
Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
| العنوان: | Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals |
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| المؤلفون: | Kosmicki, JA, Horowitz, JE, Banerjee, N, Lanche, R, Marcketta, A, Maxwell, E, Bai, X, Sun, D, Backman, JD, Sharma, D, Kury, FSP, Kang, HM, O'Dushlaine, C, Yadav, A, Mansfield, AJ, Li, AH, Watanabe, K, Gurski, L, McCarthy, SE, Locke, AE, Khalid, S, O'Keeffe, S, Mbatchou, J, Chazara, O, Huang, Y, Kvikstad, E, O'Neill, A, Nioi, P, Parker, MM, Petrovski, S, Runz, H, Szustakowski, JD, Wang, Q, Wong, E, Cordova-Palomera, A, Smith, EN, Szalma, S, Zheng, X, Esmaeeli, S, Davis, JW, Lai, Y-P, Chen, X, Justice, AE, Leader, JB, Mirshahi, T, Carey, DJ, Verma, A, Sirugo, G, Ritchie, MD, Rader, DJ, Povysil, G, Goldstein, DB, Kiryluk, K, Pairo-Castineira, E, Rawlik, K, Pasko, D, Walker, S, Meynert, A, Kousathanas, A, Moutsianas, L, Tenesa, A, Caulfield, M, Scott, R, Wilson, JF, Baillie, JK, Butler-Laporte, G, Nakanishi, T, Lathrop, M, Richards, JB, Jones, M, Balasubramanian, S, Salerno, W, Shuldiner, AR, Marchini, J, Overton, JD, Habegger, L, Cantor, MN, Reid, JG, Baras, A, Abecasis, GR, Ferreira, MAR |
| بيانات النشر: | CELL PRESS |
| سنة النشر: | 2021 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used exome sequence data to investigate associations between rare genetic variants and seven COVID-19 outcomes in 586,157 individuals, including 20,952 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome wide or when specifically focusing on (1) 13 interferon pathway genes in which rare deleterious variants have been reported in individuals with severe COVID-19, (2) 281 genes located in susceptibility loci identified by the COVID-19 Host Genetics Initiative, or (3) 32 additional genes of immunologic relevance and/or therapeutic potential. Our analyses indicate there are no significant associations with rare protein-coding variants with detectable effect sizes at our current sample sizes. Analyses will be updated as additional data become available, and results are publicly available through the Regeneron Genetics Center COVID-19 Results Browser. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0002-9297 1537-6605 |
| العلاقة: | pii: S0002-9297(21)00222-6; Kosmicki, J. A., Horowitz, J. E., Banerjee, N., Lanche, R., Marcketta, A., Maxwell, E., Bai, X., Sun, D., Backman, J. D., Sharma, D., Kury, F. S. P., Kang, H. M., O'Dushlaine, C., Yadav, A., Mansfield, A. J., Li, A. H., Watanabe, K., Gurski, L., McCarthy, S. E. ,. Ferreira, M. A. R. (2021). Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals. AMERICAN JOURNAL OF HUMAN GENETICS, 108 (7), pp.1350-1355. https://doi.org/10.1016/j.ajhg.2021.017Test.; http://hdl.handle.net/11343/278718Test |
| الإتاحة: | https://doi.org/10.1016/j.ajhg.2021.017Test http://hdl.handle.net/11343/278718Test |
| رقم الانضمام: | edsbas.B7B5C40 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00029297 15376605 |
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