دورية أكاديمية
A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression
| العنوان: | A PKD-MFF signaling axis couples mitochondrial fission to mitotic progression |
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| المؤلفون: | Pangou, Evanthia, Bielska, Olga, Guerber, Lucile, Schmucker, Stephane, Agote-Arán, Arantxa, Ye, Taozhi, Liao, Yongrong, Puig Gámez, Marta, Grandgirard, Erwan, Kleiss, Charlotte, Liu, Yansheng, Compe, Emmanuel, Zhang, Zhirong, Aebersold, Ruedi, Ricci, Romeo, Sumara, Izabela |
| المصدر: | Cell Reports, 35 (7) |
| بيانات النشر: | Cell Press |
| سنة النشر: | 2021 |
| المجموعة: | ETH Zürich Research Collection |
| مصطلحات موضوعية: | Mitochondria, Fission, MFF, PKD, mitosis, mitotic checkpoint, cell survival |
| الوصف: | Mitochondria are highly dynamic organelles subjected to fission and fusion events. During mitosis, mitochondrial fission ensures equal distribution of mitochondria to daughter cells. If and how this process can actively drive mitotic progression remains largely unknown. Here, we discover a pathway linking mitochondrial fission to mitotic progression in mammalian cells. The mitochondrial fission factor (MFF), the main mitochondrial receptor for the Dynamin-related protein 1 (DRP1), is directly phosphorylated by Protein Kinase D (PKD) specifically during mitosis. PKD-dependent MFF phosphorylation is required and sufficient for mitochondrial fission in mitotic but not in interphasic cells. Phosphorylation of MFF is crucial for chromosome segregation and promotes cell survival by inhibiting adaptation of the mitotic checkpoint. Thus, PKD/MFF-dependent mitochondrial fission is critical for the maintenance of genome integrity during cell division. ; ISSN:2666-3864 ; ISSN:2211-1247 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/wos/000653685900006; http://hdl.handle.net/20.500.11850/487127Test |
| DOI: | 10.3929/ethz-b-000487127 |
| الإتاحة: | https://doi.org/20.500.11850/487127Test https://doi.org/10.3929/ethz-b-000487127Test https://doi.org/10.1016/j.celrep.2021.109129Test https://hdl.handle.net/20.500.11850/487127Test |
| حقوق: | info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
| رقم الانضمام: | edsbas.8D7B08 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3929/ethz-b-000487127 |
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