دورية أكاديمية
Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence
| العنوان: | Adipose TSHB in Humans and Serum TSH in Hypothyroid Rats Inform About Cellular Senescence |
|---|---|
| المؤلفون: | José María Moreno-Navarrete, Laura Liñares-Pose, Mònica Sabater, Eva Rial-Pensado, Ferran Comas, Mariona Jové, Jèssica Latorre, Francisco Ortega, Wifredo Ricart, Manuel Portero-Otin, Miguel López, José Manuel Fernández-Real |
| المصدر: | Cellular Physiology and Biochemistry, Vol 51, Iss 1, Pp 142-153 (2018) |
| بيانات النشر: | Cell Physiol Biochem Press GmbH & Co KG, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Physiology LCC:Biochemistry |
| مصطلحات موضوعية: | Thyroid-stimulating hormone, Euthyroidism, Hypothyroidism, Adipose tissue, Cellular senescence, Physiology, QP1-981, Biochemistry, QD415-436 |
| الوصف: | Background/Aims: Thyroid hormones have been recently linked to senescence and longevity. Given the recent description of TSHB mRNA in human adipose tissue (AT), we aimed to investigate the relationship between local AT TSH and adipose tissue senescence. Methods: TSHB mRNA (measured by real-time PCR) and markers of adipose tissue senescence [BAX, DBC1, TP53, TNF (real-time PCR), telomere length (Telo TAGGG Telomere Length Assay) and lipidomics (liquid chromatography mass spectrometry)] were analysed in subcutaneous (SAT) and visceral (VAT) AT from euthyroid subjects. The chronic effects of TSH were also investigated in AT from hypothyroid rats and after recombinant human TSH (rhTSH) administration in human adipocytes. Results: Both VAT and SAT TSHB gene expression negatively correlated with markers of AT cellular senescence (BAX, DBC1, TP53, TNF gene expression and specific glucosylceramides) and positively associated with telomere length. Supporting these observations, both rhTSH administration in human adipocytes and increased TSH in hypothyroid rats resulted in decreased markers of cellular senescence (Bax and Tp53 mRNA) in both gonadal and subcutaneous white adipose tissue. Conclusion: These data point to a possible role of TSH in AT cellular senescence. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1015-8987 1421-9778 |
| العلاقة: | https://www.karger.com/Article/FullText/495170Test; https://doaj.org/toc/1015-8987Test; https://doaj.org/toc/1421-9778Test |
| DOI: | 10.1159/000495170 |
| الوصول الحر: | https://doaj.org/article/e95060e6d42949f0af24b6b840fffba1Test |
| رقم الانضمام: | edsdoj.95060e6d42949f0af24b6b840fffba1 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 10158987 14219778 |
|---|---|
| DOI: | 10.1159/000495170 |