التفاصيل البيبلوغرافية
| العنوان: |
Severe Rhabdomyolysis Associated with Simvastatin and Role of Ciprofloxacin and Amlodipine Coadministration |
| المؤلفون: |
Nicolas De Schryver, Xavier Wittebole, Peter Van den Bergh, Vincent Haufroid, Eric Goffin, Philippe Hantson |
| بيانات النشر: |
Case Reports in Nephrology |
| سنة النشر: |
2015 |
| المجموعة: |
Hindawi Publishing Corporation |
| الوصف: |
Simvastatin is among the most commonly used prescription medications for cholesterol reduction and the most common statin-related adverse drug reaction is skeletal muscle toxicity. Multiple factors have been shown to influence simvastatin-induced myopathy. In addition to age, gender, ethnicity, genetic predisposition, and dose, drug-drug interactions play a major role. This is particularly true for drugs that are extensively metabolized by cytochrome P450 (CYP)3A4. We describe a particularly severe case of rhabdomyolysis after the introduction of ciprofloxacin, a weak CYP3A4 inhibitor, in a patient who previously tolerated the simvastatin-amlodipine combination. |
| نوع الوثيقة: |
report |
| اللغة: |
English |
| العلاقة: |
https://doi.org/10.1155/2015/761393Test |
| DOI: |
10.1155/2015/761393 |
| الإتاحة: |
https://doi.org/10.1155/2015/761393Test |
| حقوق: |
Copyright © 2015 Nicolas De Schryver et al. |
| رقم الانضمام: |
edsbas.6B77A412 |
| قاعدة البيانات: |
BASE |
