التفاصيل البيبلوغرافية
| العنوان: |
Polysaccharides from Angelica and Astragalus exert hepatoprotective effects against carbon-tetrachloride-induced intoxication in mice |
| المؤلفون: |
Pu, Xiuying, Fan, Wenbo, Yu, Shuang, Li, Yan, Ma, Xiaolong, Liu, Lu, Ren, Jing, Zhang, Weijie |
| المصدر: |
Canadian Journal of Physiology and Pharmacology ; volume 93, issue 1, page 39-43 ; ISSN 0008-4212 1205-7541 |
| بيانات النشر: |
Canadian Science Publishing |
| سنة النشر: |
2015 |
| الوصف: |
This study aimed to investigate the effects of polysaccharide from Angelica and Astragalus (AAP) on carbon tetrachloride (CCl 4 ) induced liver damage in mice. A total of 120 Kunming mice were randomly distributed among 6 groups comprising (i) the normal control mice, (ii) the CCl 4 treatment group, (iii) the bifendate treatment group, (iv) the AAP treatment group, (v) the Angelica sinensis polysaccharide (ASP) treatment group, and (vi) the Astragalus membranaceus polysaccharide (AMP) treatment group. AAP, ASP and AMP were administered to mice treated with CCl 4 . The activities of alanine transaminase (ALT) and aspartate transaminase (AST) in the serum, and superoxide dismutase (SOD) and malondialdehyde (MDA) in the liver tissues were quantified, as well as the liver index. Hepatic histological changes were observed by staining liver sections with hematoxylin and eosin. Our results show that bifendate, AAP, ASP, and AMP significantly decreased the activities of MDA, AST, and ALT, and enhanced the activity of SOD in CCl 4 -treated mice. Bifendate, AAP, ASP, and AMP consistently ameliorated the liver injuries induced with CCl 4 . Notably, the hepatoprotective effect of AAP was stronger than that of bifendate, ASP, or AMP. In addition, AAP alleviated liver inflammation and decreased the liver indexes of mice induced with CCl 4 . These effects were at least partly due to the antioxidant properties of AAP in scavenging free radicals to ameliorate oxidative stress and to inhibit lipid peroxidation. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1139/cjpp-2014-0331 |
| الإتاحة: |
https://doi.org/10.1139/cjpp-2014-0331Test |
| حقوق: |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMiningTest |
| رقم الانضمام: |
edsbas.9D9107 |
| قاعدة البيانات: |
BASE |
