التفاصيل البيبلوغرافية
| العنوان: |
Ethanolic extract and ethyl acetate fraction of Coutoubea spicata attenuate hyperglycemia, oxidative stress, and muscle damage in alloxan-induced diabetic rats subjected to resistance exercise training program |
| المؤلفون: |
Santos, Jymmys Lopes dos, Araújo, Silvan Silva de, Silva, Ana Mara de Oliveira e, Lima, Clésio Andrade, Vieira Souza, Lúcio Marques, Costa, Rôas Araújo, Aidar Martins, Felipe José, Voltarelli, Fabrício Azevedo, Estevam, Charles dos Santos, Marçal, Anderson Carlos |
| المصدر: |
Applied Physiology, Nutrition, and Metabolism ; volume 45, issue 4, page 401-410 ; ISSN 1715-5312 1715-5320 |
| بيانات النشر: |
Canadian Science Publishing |
| سنة النشر: |
2020 |
| الوصف: |
Gentianaceae family (such as Coutoubea spicata) contains iridoids and flavonoids with antidiabetic properties. However, there is no information available about the antidiabetic effects of C. spicata when combined with resistance exercise training (RET). This study evaluated the effects of the ethanolic extract (EE) and ethyl acetate fraction (EAF) of C. spicata on biochemical markers, muscle damage, and oxidative stress in diabetic rats submitted to RET. Alloxan-induced diabetic rats were distributed into 4 groups (each group, n = 8) treated with distilled water (TD), EE, EAF, or metformin and submitted to RET. Two groups without the disease (each group, n = 8) (sedentary control and trained control), as well as a sedentary diabetic group (n = 8) were included. Body weight and glycemia were evaluated weekly. After 30 days, lipid/lipoprotein profile, aspartate aminotransferase, alanine aminotransferase, muscle damage ((creatine kinase (CK) and lactate dehydrogenase (LDH)), and oxidative stress (malondialdehyde (MDA), sulfhydryl groups (SH), and ferric reducing antioxidant power) were evaluated. MDA and SH for pancreas, liver, heart, and muscle were evaluated. C. spicata extract and fraction combined with RET recovered body weight and reduced glycemia, muscle damage (CK: 36.83% and 21.45%; LDH: 49.83% and 68.55%), and low-density lipoprotein cholesterol (70.63%; 59.18%) and improved redox status (MDA: 50.33%, 39.74%; and SH: 53.97%; 76.41%), respectively, when compared with the TD group. C. spicata plus RET promoted anti-hyperglycemic, lipid-reducing, and antioxidant effects in diabetic rats. Novelty C. spicata presents anti-hyperglycemic and lipid-lowering effects potentiated by RET. C. spicata reduces muscle injury and increases antioxidant defense. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1139/apnm-2019-0331 |
| الإتاحة: |
https://doi.org/10.1139/apnm-2019-0331Test |
| حقوق: |
http://www.nrcresearchpress.com/page/about/CorporateTextAndDataMiningTest |
| رقم الانضمام: |
edsbas.537E31A6 |
| قاعدة البيانات: |
BASE |
