Convenient preparation of aryl-substituted nortropanes by SuzukiMiyaura methodology
| العنوان: | Convenient preparation of aryl-substituted nortropanes by SuzukiMiyaura methodology |
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| المؤلفون: | William A. Kinney, Diane A. Gauthier, Tomas Hudlicky, Edward C. Lawson, Bruce E. Maryanoff, Shyamali Ghosh |
| المصدر: | Canadian Journal of Chemistry. 84:555-560 |
| بيانات النشر: | Canadian Science Publishing, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | chemistry.chemical_compound, chemistry, Bicyclic molecule, Aryl, Organic Chemistry, Nortropanes, Organic chemistry, General Chemistry, Catalysis |
| الوصف: | The synthesis of a new bicyclic vinyl boronate (5) was accomplished from N-Boc-nortropinone (6) in two steps. The SuzukiMiyaura coupling of 5 to a variety of aryl bromides and triflates afforded 3-aryl-8-azabicyclo[3.2.1]oct-2-enes in good yields by adjusting the substrate and (or) reaction conditions. Reduction to the 3-aryl-8-azabicyclo[3.2.1]octanes was achieved by hydrogenation. Interestingly, the coupling was also successful with benzyl bromides, providing entry into another group of intermediates.Key words: nortropane, SuzukiMiyaura, boronate, piperidine, GPCR, benzyl bromide. |
| تدمد: | 1480-3291 0008-4042 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::e8656cd0945e73f017f31039c49295abTest https://doi.org/10.1139/v06-045Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........e8656cd0945e73f017f31039c49295ab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14803291 00084042 |
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