LACTIC DEHYDROGENASE STUDIES IN ANIMALS INFECTED WITH TYPE 12 STREPTOCOCCI OR TREATED WITH STREPTOCOCCAL NEPHROTOXIN
| العنوان: | LACTIC DEHYDROGENASE STUDIES IN ANIMALS INFECTED WITH TYPE 12 STREPTOCOCCI OR TREATED WITH STREPTOCOCCAL NEPHROTOXIN |
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| المؤلفون: | C. K. Williamson, S. C. Elliott |
| المصدر: | Canadian Journal of Microbiology. 13:1027-1032 |
| بيانات النشر: | Canadian Science Publishing, 1967. |
| سنة النشر: | 1967 |
| مصطلحات موضوعية: | medicine.medical_specialty, Streptococcus pyogenes, medicine.medical_treatment, Immunology, Lactic dehydrogenase, Biology, Kidney, Applied Microbiology and Biotechnology, Microbiology, Blood Urea Nitrogen, Nephrotoxicity, Streptococcal Infections, Internal medicine, Genetics, medicine, Animals, Molecular Biology, Saline, Toxins, Biological, Nephritis, L-Lactate Dehydrogenase, Histocytochemistry, Renal tissue, General Medicine, Alkaline Phosphatase, Rats, Endocrinology, Rabbits, Ldh activity |
| الوصف: | A histochemical and biochcrl~ical st~~dy of the reactions of IVistar rats and New Zealand rabbits to Strepto~occ~is pyoge?zes, type 12, strain H-8, and the nephrotoxin (NT) elaborated by these organisms is presented. il significant lactic dehydrogenase (LDH) increase was found in the sera of all test rats 27 days following treatment with strcptococcal NT. However, before this increased activity was detected, a marlccd decrease in LDH activity \\as obtained as early as 1 day after the last NT injection. This decrease was modest in rats treated \\it11 1.0 n1g NT, but it was great \I hen the dosage of KT was increased to 5:O mg. Serum LDIl values also decreased progressively, up to about 2 weeks, 111 rabbits infected with nephritogenic streptococci or treated with streptococcal ncphrotoxin. Such serum LDI-I fluctuatio~ls did not occur in animals treated with saline or Todd-I-Ielvitt broth. Histoche~nical studies also suggested an initial inhibition by NT of LDI-I activity in renal tissue. |
| تدمد: | 1480-3275 0008-4166 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a793b3d0368f9090f48626aaa01ba4eaTest https://doi.org/10.1139/m67-137Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a793b3d0368f9090f48626aaa01ba4ea |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14803275 00084166 |
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