Effects of muscle sympathetic burst size and burst pattern on time-to-peak sympathetic transduction
| العنوان: | Effects of muscle sympathetic burst size and burst pattern on time-to-peak sympathetic transduction |
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| المؤلفون: | Massimo Nardone, Philip J. Millar, Joseph A Cacoilo, Anthony V. Incognito, Lauro C. Vianna, André L. Teixeira |
| المصدر: | Applied Physiology, Nutrition, and Metabolism. :1-7 |
| بيانات النشر: | Canadian Science Publishing, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Sympathetic nervous system, Sympathetic Nervous System, Time Factors, Physiology, Endocrinology, Diabetes and Metabolism, Blood Pressure, 030204 cardiovascular system & hematology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Physiology (medical), Humans, Medicine, Cardiac Output, Muscle, Skeletal, Retrospective Studies, Sex Characteristics, Nutrition and Dietetics, business.industry, Sympathetic nerve activity, General Medicine, Microneurography, medicine.anatomical_structure, Blood pressure, Regional Blood Flow, Time to peak, Female, business, Neuroscience, Transduction (physiology), Algorithms, 030217 neurology & neurosurgery, Signal Transduction |
| الوصف: | The current study evaluated the influence of resting muscle sympathetic nerve activity (MSNA) burst size and firing pattern on time-to-peak sympathetic transduction in 36 young healthy men and women. Participants underwent a 5–10 min resting baseline with beat-to-beat measures of heart rate, mean arterial pressure (MAP), and MSNA (microneurography). Cardiac output and total vascular conductance were calculated using the Modelflow algorithm. Sympathetic transduction was quantified using the burst-triggered signal averaging technique to examine the changes in MAP, cardiac output, and total vascular conductance for 15 cardiac cycles after each MSNA burst or non-burst. A stepwise increase in the peak MAP (i.e., sympathetic transduction) was observed throughout all quartiles of normalized MSNA burst area (quartile 1 (Q1): 1.7 ± 1.3 mm Hg; Q2: 2.1 ± 1.3 mm Hg; Q3: 2.6 ± 1.4 mm Hg; Q4: 3.5 ± 1.4 mm Hg; P < 0.01). The largest quartile of normalized MSNA burst area demonstrated faster time-to-peak MAP responses (5.7 ± 2.5 s) than both Q1 (10.1 ± 3.9 s, P < 0.01) and Q2 (9.3 ± 4.1 s, P < 0.01), as well as, faster time-to-peak cardiac output and time-to-nadir total vascular conductance compared with Q1 and Q2 (All P < 0.05). Larger clusters of sympathetic bursts (i.e., triplets and ≥ quadruplets) did not have increased time-to-peak transduction compared with singlets and doublet bursts across all MSNA quartiles. These results highlight intraindividual variability in the time-course of sympathetic transduction and reveal an intrinsic property of larger sympathetic bursts to increase time-to-peak sympathetic transduction in humans. Novelty: Muscle sympathetic burst size can modulate time-to-peak sympathetic transduction in young healthy men and women. These observations appear independent of the pattern of sympathetic firing. |
| تدمد: | 1715-5320 1715-5312 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e9df9c49bb46f3e045dd8c4899eb64Test https://doi.org/10.1139/apnm-2020-0721Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d0e9df9c49bb46f3e045dd8c4899eb64 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17155320 17155312 |
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