دورية أكاديمية
Can lymphovascular invasion replace the prognostic value of lymph node involvement in patients with upper tract urothelial carcinoma after radical nephroureterectomy?
| العنوان: | Can lymphovascular invasion replace the prognostic value of lymph node involvement in patients with upper tract urothelial carcinoma after radical nephroureterectomy? |
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| المساهمون: | College of Medicine, Dept. of Urology, Eun Sang Yoo, Yun-Sok Ha, Jun Nyung Lee, Bum Soo Kim, Bup Wan Kim, Seok-Soo Byun, Young Deuk Choi, Ho Won Kang, Seok-Joong Yun, Wun-Jae Kim, Jeong Hyun Kim, Tae Gyun Kwon, Choi, Young Deuk |
| بيانات النشر: | Canadian Medical Association Canada |
| سنة النشر: | 2016 |
| الوصف: | INTRODUCTION: This study aimed to evaluate whether lymphovascular invasion (LVI) can replace lymph node (LN) involvement as a prognostic marker in patients who do not undergo lymph node dissection (LND) during surgery in patients with upper tract urothelial carcinoma (UTUC). METHODS: A total of 505 patients who underwent radical nephroureterectomy (RNU) were recruited from four academic centres and divided into four groups: node negative (N0, Group 1); node positive (N+, Group 2); no LND without LVI (NxLVI-, Group 3); and no LND with LVI (NxLVI+, Group 4). RESULTS: Patients in Group 2 had larger tumours, a higher incidence of left-sided involvement, more aggressive T stage and grade, and a higher positive surgical margin rate than patients in other groups. Pathological features (T stage and grade) were poorer in Group 4 than in Groups 1 and 3. Compared to other groups, Group 2 had the worst prognostic outcomes regarding locoregional/distant metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OS). LVI and LN status in Group 4 was not associated with MFS in multivariate analysis. Among Nx diseases, LVI was not an independent predictor of MFS or CCS. The small number of cases in Groups 2 and 4 is a major limitation of this study. CONCLUSIONS: Clinical outcomes according to LVI did not correlate with those outcomes predicted by LN involvement in patients with UTUC. Therefore, LVI may not be used as a substitute for nodal status in patients who do not undergo LND at the time of surgery. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English French |
| تدمد: | 1911-6470 1920-1214 |
| العلاقة: | CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL; J02986; 2007; OAK-2016-08588; https://ir.ymlib.yonsei.ac.kr/handle/22282913/153061Test; T201606098; CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL, Vol.10(7~8) : 229-236, 2016 |
| DOI: | 10.5489/cuaj.3557 |
| الإتاحة: | https://doi.org/10.5489/cuaj.3557Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/153061Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ |
| رقم الانضمام: | edsbas.39D9AA6 |
| قاعدة البيانات: | BASE |
| تدمد: | 19116470 19201214 |
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| DOI: | 10.5489/cuaj.3557 |