التفاصيل البيبلوغرافية
| العنوان: |
Late recurrence of cervical cancer, retrospective study from a single cancer institute. |
| المؤلفون: |
Elmaghraby, Nermine, Nirmalanantham, P., Sur, M., Schnarr, K., Elit, L., Aziz, T., Kazerouni, H., Wright, J., Lytwyn, A. |
| المصدر: |
Canadian Journal of Pathology; 2018 Supplement, Vol. 10, p36-36, 1/3p |
| مصطلحات موضوعية: |
CERVICAL cancer diagnosis, CANCER in women, CANCER relapse, CLINICAL pathology, IMMUNOHISTOCHEMISTRY |
| مستخلص: |
Background: Women with cervical cancer have 8-25% recurrence risk, and 89%-99% recurrences present within 5 years of the primary cancer. Literature is limited on late recurrences 5 years after the primary cancer. Objectives: Describe clinical, radiologic, pathologic characteristics of late recurrent cervical cancer. Methodology: This is a retrospective study at a single cancer institute. The computerized pathology database was searched from years 1995 to 2011, cases then handsearched for late recurrences. Clinical, radiology and pathology reports were reviewed. Results: We identified 32 patients with recurrent cervical cancer; of these 7 presented 7-36 years after treatment. Four were squamous (SCC) and 3 adenocarcinomas. Six were stage IB or higher; one was IA with lymphovascular invasion. Recurrences occurred in vaginal vault, vesicovaginal fistula, bladder neck, cervix, femur, ovary, iliac and para-aortic lymph nodes. Ancillary testing to exclude a second primary and confirm cervical origin was used in 3 patients whose primary cervical cancers had occurred 8,13, and 19 years earlier: oncogenic human papillomavirus tissue testing was positive in 2 cases, and in the third case p16 was positive together with negative immunohistochemistry specific for other sites. Conclusion: Late cervical cancer recurrence is uncommon and a second primary may need to be considered. Pathology work up will depend on the clinical, imaging and morphological context. Testing for p16 and HPV may be useful. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
