Unlike pregnant adult women, pregnant adolescent girls cannot maintain glycine flux during late pregnancy because of decreased synthesis from serine
| العنوان: | Unlike pregnant adult women, pregnant adolescent girls cannot maintain glycine flux during late pregnancy because of decreased synthesis from serine |
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| المؤلفون: | Raquel Gibson, Grace J. Tang, Tameka M. Baker, Shaji Chacko, Jean W. Hsu, Alan Jackson, Minerva Thame, Farook Jahoor |
| المصدر: | British Journal of Nutrition. 115:759-763 |
| بيانات النشر: | Cambridge University Press (CUP), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, medicine.medical_specialty, Adolescent, Pregnancy Trimester, Third, Glycine, Medicine (miscellaneous), 030209 endocrinology & metabolism, Models, Biological, Adult women, Serine, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Internal medicine, medicine, Humans, Fetus, Nutrition and Dietetics, business.industry, Maternal Nutritional Physiological Phenomena, medicine.disease, Late pregnancy, Pregnancy Trimester, First, 030104 developmental biology, Endocrinology, Pregnant adolescent, Female, Linear growth, business |
| الوصف: | During pregnancy, glycine and serine become more important because they are the primary suppliers of methyl groups for the synthesis of fetal DNA, and more glycine is required for fetal collagen synthesis as pregnancy progresses. In an earlier study, we reported that glycine flux decreased by 39 % from the first to the third trimester in pregnant adolescent girls. As serine is a primary precursor for glycine synthesis, the objective of this study was to measure and compare glycine and serine fluxes and inter-conversions in pregnant adolescent girls and adult women in the first and third trimesters. Measurements were made after an overnight fast by continuous intravenous infusions of 2H2-glycine and 15N-serine in eleven adolescent girls (17·4 (se 0·1) years of age) and in ten adult women (25·8 (se 0·5) years of age) for 4 h. Adolescent girls had significantly slower glycine flux and they made less glycine from serine in the third (PP=0·04) and was significantly associated with third trimester glycine flux. These findings suggest that the pregnant adolescent cannot maintain glycine flux in late pregnancy compared with early pregnancy because of decreased synthesis from serine. It is possible that the inability to maintain glycine synthesis makes her fetus vulnerable to impaired cartilage synthesis, and thus linear growth. |
| تدمد: | 1475-2662 0007-1145 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564836af801fe80fd07b71a24ff5e476Test https://doi.org/10.1017/s0007114515005279Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....564836af801fe80fd07b71a24ff5e476 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752662 00071145 |
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