دورية أكاديمية
Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation
| العنوان: | Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation |
|---|---|
| المؤلفون: | Saravanakumar, Murugesan, Raja, Boobalan, Manivannan, Jeganathan, Silambarasan, Thangarasu, Prahalathan, Pichavaram, Kumar, Subramanian, Mishra, Santosh Kumar |
| المصدر: | British Journal of Nutrition ; volume 114, issue 9, page 1385-1394 ; ISSN 0007-1145 1475-2662 |
| بيانات النشر: | Cambridge University Press (CUP) |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Nutrition and Dietetics, Medicine (miscellaneous) |
| الوصف: | In our previous studies, veratric acid (VA) shows beneficial effect on hypertension and its associated dyslipidaemia. In continuation, this study was designed to investigate the effect of VA, one of the major benzoic acid derivatives from vegetables and fruits, on cardiovascular remodelling in hypertensive rats, primarily assessed by functional studies using Langendorff isolated heart system and organ bath system. Hypertension was induced in male albino Wistar rats by oral administration of N ω -nitro- l -arginine methyl ester hydrochloride ( l -NAME) (40 mg/kg body weight (b.w.)) in drinking water for 4 weeks. VA was orally administered at a dose of 40 mg/kg b.w. l -NAME-treated rats showed impaired cardiac ventricular and vascular function, evaluated by Langendorff isolated heart system and organ bath studies, respectively; a significant increase in the lipid peroxidation products such as thiobarbituric acid-reactive substances and lipid hydroperoxides in aorta; and a significant decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase and levels of GSH, vitamin C and vitamin E in aorta. Fibrotic remodelling of the aorta and heart were assessed by Masson’s Trichrome staining and Van Gieson’s staining, respectively. In addition, l -NAME rats showed increased heart fibronectin expression assessed by immunohistochemical analysis. VA supplementation throughout the experimental period significantly normalised cardiovascular function, oxidative stress, antioxidant status and fibrotic remodelling of tissues. These results of the present study conclude that VA acts as a protective agent against hypertension-associated cardiovascular remodelling. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1017/s0007114515003086 |
| الإتاحة: | https://doi.org/10.1017/s0007114515003086Test https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0007114515003086Test |
| حقوق: | https://www.cambridge.org/core/termsTest |
| رقم الانضمام: | edsbas.EACF4999 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1017/s0007114515003086 |
|---|