41 Does exercise improve progression free survival (PFS) and quality of life (QOL) in patients with glioblastoma? A trial in progress
| العنوان: | 41 Does exercise improve progression free survival (PFS) and quality of life (QOL) in patients with glioblastoma? A trial in progress |
|---|---|
| المؤلفون: | Gelareh Zadeh, Kim Edelstein, Felicity Backhouse, Warren P. Mason, Normand Laperriere, Alejandro Berlin, Catherine Maurice, Ilyse Lax, Barbara-Ann Millar, David B. Shultz, Gregory R. Pond, Lori J. Bernstein, Kristin L. Campbell |
| المصدر: | Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 45:S8-S8 |
| بيانات النشر: | Cambridge University Press (CUP), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, business.industry, General Medicine, medicine.disease, Neurology, Quality of life, Internal medicine, medicine, In patient, Neurology (clinical), Progression-free survival, business, Glioblastoma |
| الوصف: | Background: Glioblastoma is the most common adult malignant glioma, with poor prognosis and adverse neurological sequelae. Physical activity improves outcomes in patients with other cancers, but has not been evaluated in GBM. This prospective, single-arm intervention trial examines feasibility and preliminary efficacy of exercise on PFS, cognition and QOL in newly diagnosed GBM patients. Method: Participants are English-speaking GBM patients scheduled for concurrent chemoradiation at PMH, 18-65 years old, ECOG ≤ 2. The 3-month home-based exercise program includes aerobic and resistance training, tailored to prior fitness level, current physical status, and individual interests. Assessments of physical and neurocognitive functions, mood, fatigue, sleep, and QOL, occur within 2 weeks of starting chemoradiation, and approximately 3, 6, 12, and 18 months later, or until tumor progression. Feasibility will be assessed by accrual, retention, and adherence rates. Outcomes include PFS (RANO criteria), change in cognition (reliable change index method), physical activity and sleep (actigraphy, self-report questionnaires). Time-to-event outcomes will be estimated (Kaplan-Meier), and mixed modelling will explore individual and disease variables that contribute to outcomes. Results: During the first five months of recruitment, 13 of 19 eligible patients consented. Nine completed the exercise program. One patient died after the intervention and none of the others progressed. No exercise-related serious adverse events occurred. Preliminary results will be presented at the meeting. Discussion: Exercise appears feasible for GBM patients. Effects on survival, performance status, cognition, sleep, mood, and QOL are ongoing. Results may guide physical activity recommendations in GBM and generate avenues for translational research. |
| تدمد: | 2057-0155 0317-1671 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::3381b9d4e22a808f8d0d64bf865f9ff7Test https://doi.org/10.1017/cjn.2018.282Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........3381b9d4e22a808f8d0d64bf865f9ff7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20570155 03171671 |
|---|