دورية أكاديمية
Treatment of hypoplastic left heart syndrome: a systematic review and meta-analysis of randomised controlled trials
| العنوان: | Treatment of hypoplastic left heart syndrome: a systematic review and meta-analysis of randomised controlled trials |
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| المؤلفون: | Kim, A. Y., Woo, W., Saxena, A., Tanidir, I. C., Yao, A., Kurniawati, Y., Thakur, V., Shin, Y. R., Shin, J. I., Jung, J. W., Barron, D. J. |
| المصدر: | Cardiology in the Young ; volume 34, issue 3, page 659-666 ; ISSN 1047-9511 1467-1107 |
| بيانات النشر: | Cambridge University Press (CUP) |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Cardiology and Cardiovascular Medicine, General Medicine, Pediatrics, Perinatology and Child Health |
| الوصف: | Background: This meta-analysis aimed to consolidate existing data from randomised controlled trials on hypoplastic left heart syndrome. Methods: Hypoplastic left heart syndrome specific randomised controlled trials published between January 2005 and September 2021 in MEDLINE, EMBASE, and Cochrane databases were included. Regardless of clinical outcomes, we included all randomised controlled trials about hypoplastic left heart syndrome and categorised them according to their results. Two reviewers independently assessed for eligibility, relevance, and data extraction. The primary outcome was mortality after Norwood surgery. Study quality and heterogeneity were assessed. A random-effects model was used for analysis. Results: Of the 33 included randomised controlled trials, 21 compared right ventricle-to-pulmonary artery shunt and modified Blalock–Taussig-Thomas shunt during the Norwood procedure, and 12 regarded medication, surgical strategy, cardiopulmonary bypass tactics, and ICU management. Survival rates up to 1 year were superior in the right ventricle-to-pulmonary artery shunt group; this difference began to disappear at 3 years and remained unchanged until 6 years. The right ventricle-to-pulmonary artery shunt group had a significantly higher reintervention rate from the interstage to the 6-year follow-up period. Right ventricular function was better in the modified Blalock–Taussig-Thomas shunt group 1–3 years after the Norwood procedure, but its superiority diminished in the 6-year follow-up. Randomised controlled trials regarding medical treatment, surgical strategy during cardiopulmonary bypass, and ICU management yielded insignificant results. Conclusions: Although right ventricle-to-pulmonary artery shunt appeared to be superior in the early period, the two shunts applied during the Norwood procedure demonstrated comparable long-term prognosis despite high reintervention rates in right ventricle-to-pulmonary artery shunt due to pulmonary artery stenosis. For medical/perioperative management of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1017/s1047951123002986 |
| الإتاحة: | https://doi.org/10.1017/s1047951123002986Test https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S1047951123002986Test |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.A29A614 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1017/s1047951123002986 |
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