An Outbreak ofPichia anomalaFungemia in a Brazilian Pediatric Intensive Care Unit
| العنوان: | An Outbreak ofPichia anomalaFungemia in a Brazilian Pediatric Intensive Care Unit |
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| المؤلفون: | Arnaldo Lopes Colombo, Cledja Soares de Amorim, Alessandro C. Pasqualotto, Teresa C. T. Sukiennik, Luiz Carlos Severo |
| المصدر: | Infection Control & Hospital Epidemiology. 26:553-558 |
| بيانات النشر: | Cambridge University Press (CUP), 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Pediatrics, Antifungal Agents, Pichia anomala, Epidemiology, Attack rate, Communicable Diseases, Emerging, Pichia, Disease Outbreaks, law.invention, 0302 clinical medicine, Risk Factors, law, Medicine, Hospital Mortality, 030212 general & internal medicine, DNA, Fungal, Fungemia, Pediatric intensive care unit, Cross Infection, biology, Mortality rate, Candidiasis, Intensive care unit, Random Amplified Polymorphic DNA Technique, Infectious Diseases, Female, Seasons, Brazil, Microbiology (medical), Catheterization, Central Venous, medicine.medical_specialty, 030106 microbiology, Microbial Sensitivity Tests, Intensive Care Units, Pediatric, 03 medical and health sciences, Age Distribution, Amphotericin B, Humans, Anomala, business.industry, Infant, Outbreak, biology.organism_classification, medicine.disease, Case-Control Studies, Multivariate Analysis, business |
| الوصف: | Objective:To report an outbreak ofPichia anomalafungemia that occurred in a Brazilian pediatric intensive care unit (ICU) from October 2002 to January 2004.Design:Unmatched case-control study.Methods:We randomly selected four control-patients for each case-patient from a list of all patients admitted to the ICU for at least 48 hours during the outbreak. A second control group was composed of all consecutive patients with nosocomial candidemia in the ICU during the outbreak. An environmental study was performed, and genetic relatedness among the clinical isolates was characterized by randomly amplified polymorphic DNA assay.Results:During the study period, 1,046 children were admitted to the pediatric ICU, 17 of whom developedP. anomalafungemia (attack rate, 1.6%). The median age was 1.1 years, and the main underlying conditions were congenital malformations (35.3%) and neoplastic diseases (11.8%). The overall mortality rate was 41.2%. Two patients received no antifungal treatment; all of the others were treated with amphotericin B. On multivariate analysis, only the presence of a central venous catheter was significantly associated withP. anomalafungemia. The yeast was not found on healthcare workers' hands or in the environment. Molecular studies showed that the outbreak was caused by a single strain. The distribution of risk factors was similar between patients withP. anomalafungemia and control-patients with candidemia.Conclusions:This study highlights the importance ofP. anomalaas an emerging nosocomial fungal pathogen. Patients withP. anomalafungemia seem to have risk factors in common with those who have candidemia. |
| تدمد: | 1559-6834 0899-823X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1788f574eaf09ef0e8caa6c73861112bTest https://doi.org/10.1086/502583Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1788f574eaf09ef0e8caa6c73861112b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15596834 0899823X |
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