دورية أكاديمية
A comprehensive approach to the bioavailability and cardiometabolic effects of the bioactive compounds present in espresso coffee and confectionery-derived coffee
| العنوان: | A comprehensive approach to the bioavailability and cardiometabolic effects of the bioactive compounds present in espresso coffee and confectionery-derived coffee |
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| المؤلفون: | Mena, Pedro, Tassotti, Michele, Rosi, Alice, Martini, Daniela, Righetti, Laura, Antonini, Monica, Dall'Asta, Margherita, Bresciani, Letizia, Fantuzzi, Federica, Spigoni, Valentina, Gil-Izquierdo, Angel, Domínguez-Perles, Raúl, Tornel, Pedro Luis, Del Pozo-Luengo, Soledad, Angelino, Donato, Del Bo', Cristian, Dall'Asta, Chiara, Riso, Patrizia, Cas, Alessandra Dei, Bonadonna, Riccardo, Brighenti, Furio, Del Rio, Daniele |
| المصدر: | Proceedings of the Nutrition Society ; volume 79, issue OCE2 ; ISSN 0029-6651 1475-2719 |
| بيانات النشر: | Cambridge University Press (CUP) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Nutrition and Dietetics, Medicine (miscellaneous) |
| الوصف: | Coffee is an important source of bioactive compounds, including caffeine, trigonelline, and phenolic compounds. Several studies have highlighted the preventive effects of coffee consumption on major cardiometabolic diseases, but the impact of coffee dosage on markers of cardiometabolic risk is not well understood. Moreover, the pool of coffee-derived circulating metabolites in real-life settings is unknown. This study evaluated the bioavailability and effects on recognised cardiometabolic markers of coffee bioactives, considering different levels of consumption. An innovative experimental design, including both a chronic and an acute sub-study, and a comprehensive analytical approach were used. A 3-arm, randomised, crossover trial was conducted in 21 healthy volunteers (age, 23 ± 2 y; BMI, 22.3 ± 2.5 kg/m 2 ) (Mena et al., Trials 2017, 18, 527). Volunteers were assigned to consume 3 treatments for 4 weeks, including 1 cup of espresso coffee/day, 3 cups of espresso coffee/day, and 1 cup of espresso coffee plus 2 cocoa-based confectionary products containing-coffee twice per day. The last day of each treatment, blood and urine samples were collected at specific time points for 24 hours. Dietary intake, body weight, BMI, waist circumference, blood pressure, fasting glucose, insulin, LDL- and HDL-cholesterol, triglycerides, nitric oxide, inflammatory markers (IL-8, TNFα, VEGF), trimethylamine- N -oxide (TMAO), DNA damage, DNA catabolites, and eicosanoids were assessed. The pool of coffee-derived circulating metabolites was also assessed in acute conditions. Untargeted metabolomics was performed. Energy intake did not change among treatments after 4 weeks, while significant differences were observed in the intake of saturated fatty acids and carbohydrates. The effect of different coffee dosages on the set of cardiometabolic markers assessed was negligible. Plasma and urinary pharmacokinetic profiles were evaluated for 6 caffeine metabolites, 3 trigonelline derivatives, and up to 40 phenolic metabolites. ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1017/s0029665120000713 |
| الإتاحة: | https://doi.org/10.1017/s0029665120000713Test https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0029665120000713Test |
| حقوق: | https://www.cambridge.org/core/termsTest |
| رقم الانضمام: | edsbas.742F9953 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1017/s0029665120000713 |
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