Intake of α-linolenic acid and other fatty acids in relation to the risk of bladder cancer: results from the New Hampshire case–control study
| العنوان: | Intake of α-linolenic acid and other fatty acids in relation to the risk of bladder cancer: results from the New Hampshire case–control study |
|---|---|
| المؤلفون: | Maurice P. Zeegers, Maree Brinkman, Alan R. Schned, Margaret R. Karagas, Michael S. Zens, Raoul C. Reulen |
| المساهمون: | Complexe Genetica, RS: NUTRIM - R4 - Gene-environment interaction |
| المصدر: | British Journal of Nutrition, 106(7), 1070-1077. Cambridge University Press |
| بيانات النشر: | Cambridge University Press (CUP), 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Male, Linoleic acid, BIOMARKERS, UNITED-STATES, Medicine (miscellaneous), Physiology, Essential fatty acids, Article, DIET, Polyunsaturated fat, chemistry.chemical_compound, Sex Factors, FOOD, Risk Factors, Odds Ratio, medicine, Humans, New Hampshire, ARSENIC EXPOSURE, METAANALYSIS, POPULATION, Aged, Nutrition and Dietetics, Bladder cancer, business.industry, Cholesterol, Fatty Acids, Smoking, Confounding, Case-control study, WOMEN, alpha-Linolenic Acid, MEN, Feeding Behavior, Odds ratio, Middle Aged, medicine.disease, PROSTATE-CANCER, Urinary Bladder Neoplasms, Quartile, Biochemistry, chemistry, Case-Control Studies, Female, business |
| الوصف: | The role of dietary fat in bladder cancer aetiology is currently unclear due to few studies, equivocal findings and a lack of information on important dietary fatty acids. The aim of the present study was to investigate the association between the intake of major dietary fats and fatty acids and the risk of bladder cancer. A case–control study was conducted in New Hampshire, USA. Dietary data were collected from 322 cases and 239 controls, and OR and 95 % CI were calculated using unconditional logistic regression. Adjustment was made for potential confounders: sex, age, smoking status, pack-years smoked, cholesterol and energy intake. Statistically significant reduced odds of bladder cancer were observed for high intakes (highest quartile v. lowest quartile) of α-linolenic acid (ALA) (OR 0·26, 95 % CI 0·10, 0·65; P for trend = 0·01) and vegetable fat (OR 0·39, 95 % CI 0·18, 0·86; P for trend = 0·03). Borderline statistically significant reduced odds were detected for polyunsaturated fat (OR 0·43, 95 % CI 0·19, 0·98; P for trend = 0·07) and linoleic acid (OR 0·43, 95 % CI 0·19, 0·96; P for trend = 0·06). These fats and fatty acids were highly correlated and following adjustment for each other, the only potential inverse association to remain was for ALA. The present findings suggest that ALA may have a protective role against developing bladder cancer; however, further investigation and replication in other epidemiological studies are required. Future research should focus on the type, source and quantities of different dietary fatty acids consumed. |
| تدمد: | 1475-2662 0007-1145 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eae1019446b71586eba6b4d36e17f5dTest https://doi.org/10.1017/s0007114511001346Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0eae1019446b71586eba6b4d36e17f5d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752662 00071145 |
|---|