Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut–liver axis
| العنوان: | Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut–liver axis |
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| المؤلفون: | Julie Rodriguez, Nathalie M. Delzenne, Christelle Knudsen, Audrey M. Neyrinck, Martin Beaumont, Laure B. Bindels |
| المساهمون: | UCL - SSS/LDRI - Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain = Catholic University of Louvain (UCL), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Wallonia (FOOD4GUT project) 1318148 / EU 613979 MyNewGut FP7-609398 |
| المصدر: | The Proceedings of the Nutrition Society, Vol. 78, no. 3, p. 319-328 (2019) Proceedings of the Nutrition Society Proceedings of the Nutrition Society, Cambridge University Press (CUP), 2019, 78 (3), pp.319-328. ⟨10.1017/S0029665118002756⟩ |
| بيانات النشر: | Cambridge University Press (CUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | GLP glucagon-like peptide, 0301 basic medicine, non-alcoholic fatty liver desease, Medicine (miscellaneous), Gut flora, Bioinformatics, Mice, GPR G protein-coupled receptors, 0302 clinical medicine, NASH non-alcoholic steatohepatitis, Non-alcoholic Fatty Liver Disease, Nutrition and Dietetics, Fatty liver, 3. Good health, Liver, NAFLD non-alcoholic fatty liver disease, prebiotic, ALT alanine aminotransferase, 030211 gastroenterology & hepatology, medicine.symptom, ITF inulin-type fructans, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Inflammation, Gut microbiota, Biology, digestive system, 03 medical and health sciences, BA bile acid, medicine, Animals, Humans, gut microbiota, Host (biology), Probiotics, FXR farnesoid X receptor, AST aspartate aminotransferase, Metabolism, medicine.disease, biology.organism_classification, Obesity, Gastrointestinal Microbiome, Disease Models, Animal, Prebiotics, 030104 developmental biology, AhR aryl hydrocarbon receptor, inflammation, LPS lipopolysaccharides, Farnesoid X receptor, Energy Metabolism, Function (biology), Non-alcoholic fatty liver disease |
| الوصف: | This review presents mechanistic studies performed in vitro and in animal models, as well as data obtained in patients that contribute to a better understanding of the impact of nutrients interacting with the gut microbiota on metabolic and behavioural alterations linked to obesity. The gut microbiota composition and function are altered in several pathological conditions including obesity and related diseases i.e. non-alcoholic fatty liver diseases (NAFLD). The gut–liver axis is clearly influenced by alterations of the gut barrier that drives inflammation. In addition, recent papers propose that specific metabolites issued from the metabolic cooperation between the gut microbes and host enzymes, modulate inflammation and gene expression in the liver. This review illustrates how dietary intervention with prebiotics or probiotics influences host energy metabolism and inflammation. Indeed, intervention studies are currently underway in obese and NAFLD patients to unravel the relevance of the changes in gut microbiota composition in the management of metabolic and behavioural disorders by nutrients interacting with the gut microbiota. In conclusion, diet is among the main triggers of NAFLD and the gut microbiota is modified accordingly, underlining the importance of the concomitant study of the nutrients and microbial impact on liver health and metabolism, in order to propose innovative, clinically relevant, therapeutic approaches. |
| تدمد: | 1475-2719 0029-6651 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e56d9d5d0ddd04fa33e558922e0d67Test https://doi.org/10.1017/s0029665118002756Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....18e56d9d5d0ddd04fa33e558922e0d67 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752719 00296651 |
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