A literature review of flavonoids and lifespan in model organisms
| العنوان: | A literature review of flavonoids and lifespan in model organisms |
|---|---|
| المؤلفون: | Nils Duckstein, Kathrin Pallauf, Gerald Rimbach |
| المصدر: | Proceedings of the Nutrition Society. 76:145-162 |
| بيانات النشر: | Cambridge University Press (CUP), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Antioxidant, medicine.medical_treatment, media_common.quotation_subject, Longevity, ved/biology.organism_classification_rank.species, Flavonoid, Defence mechanisms, Medicine (miscellaneous), Biology, Antioxidants, Mice, 03 medical and health sciences, Anti-Infective Agents, medicine, Animals, Humans, heterocyclic compounds, Caenorhabditis elegans, Model organism, Gene, media_common, Flavonoids, Genetics, chemistry.chemical_classification, 030109 nutrition & dietetics, Nutrition and Dietetics, Plant Extracts, ved/biology, fungi, Hormesis, food and beverages, Drosophila melanogaster, 030104 developmental biology, Biochemistry, chemistry, Dietary Supplements, Healthy ageing |
| الوصف: | Epidemiological data on consumption of flavonoid-containing food points to the notion that some of these secondary plant metabolites may favour healthy ageing. The aim of the present paper was to review the literature on lifespan extension by flavonoids in worms, flies and mice. In most studies, worms and flies experienced lifespan extension when supplemented with flavonoids either as extracts or single compounds. Studies with mutant worms and flies give hints as to which gene products may be regulated by flavonoids and consequently enhance longevity. We discuss the data considering putative mechanisms that may underlie flavonoid action such as energy-restriction-like effects, inhibition of insulin-like-growth-factor signalling, induction of antioxidant defence mechanisms, hormesis as well as antimicrobial properties. However, it remains uncertain whether human lifespan could be prolonged by increased flavonoid intake. |
| تدمد: | 1475-2719 0029-6651 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa49ba3316922c99627b43f91eab69c5Test https://doi.org/10.1017/s0029665116000720Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fa49ba3316922c99627b43f91eab69c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752719 00296651 |
|---|