Effect of time-restricted feeding on metabolic risk and circadian rhythm associated with gut microbiome in healthy males
| العنوان: | Effect of time-restricted feeding on metabolic risk and circadian rhythm associated with gut microbiome in healthy males |
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| المؤلفون: | Fatima Majeed, Ijaz-Ul Haq, Falak Zeb, Aochang Chen, Xiaoyue Wu, Min Li, Lijun Chen, Sadia Fatima, Qing Feng |
| المصدر: | British Journal of Nutrition. 123:1216-1226 |
| بيانات النشر: | Cambridge University Press (CUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Medicine (miscellaneous), Physiology, 030209 endocrinology & metabolism, Prevotellaceae, Gut flora, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Bacterial Proteins, Metabolic Diseases, RNA, Ribosomal, 16S, Intermittent fasting, Gene expression, medicine, Humans, Genetic Predisposition to Disease, Circadian rhythm, Nutrition and Dietetics, biology, medicine.diagnostic_test, Sirtuin 1, Cardiometabolic Risk Factors, Fasting, biology.organism_classification, medicine.disease, Lipids, Obesity, Healthy Volunteers, Circadian Rhythm, Gastrointestinal Microbiome, 030104 developmental biology, Liver, biology.protein, Lipid profile, Biomarkers |
| الوصف: | Time-restricted feeding (TRF) confers protection against nutritional challenges that predispose obesity and metabolic risks through involvement of circadian locomotor output cycles protein kaput genes and gut microbiome, but the underlying mechanism is not clearly understood. Therefore, the present study examined the effects of TRF on metabolic markers and circadian rhythm associated with gut microbiota in healthy males. Two groups (TRF, n 56; non-TRF, n 24) of male adults were enrolled. The TRF group provided blood at pre-TRF and post-TRF, while non-TRF one time after 25 d of trial. Serum lipid and liver profiles were determined. Real time-PCR was applied for circadian and inflammatory gene expression. The 16S rRNA genes were sequenced on the Illumina Miseq v3 platform to comprehensively catalogue the composition and abundance of bacteria in stool. We showed that TRF ameliorated the serum lipid and liver profiles of the individuals. In the TRF group, gut microbial richness was significantly enhanced, with enrichment of Prevotellaceae and Bacteroideaceae. TRF enhanced circadian gene expression probably by activation of sirtuin-1, which is positively associated with gut microbiome richness. TRF could be a safe remedy for the prevention of metabolic diseases related to dyslipidaemia, as it regulates circadian rhythm associated with gut microbiome modulation. |
| تدمد: | 1475-2662 0007-1145 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef431ac1a7208ada6242a180fc6480aTest https://doi.org/10.1017/s0007114519003428Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....5ef431ac1a7208ada6242a180fc6480a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752662 00071145 |
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