كتاب
Assessing molecular variability in cancer genomes
| العنوان: | Assessing molecular variability in cancer genomes |
|---|---|
| المؤلفون: | Barbour, A D, Tavaré, S |
| المساهمون: | Bingham, N H, Goldie, C M, Kingman, J F C, Bingham, N H ( N H ), Goldie, C M ( C M ), Kingman, J F C ( J F C ) |
| المصدر: | Barbour, A D; Tavaré, S (2010). Assessing molecular variability in cancer genomes. In: Bingham, N H; Goldie, C M; Kingman, J F C. Probability and mathematical genetics. Cambridge: Cambridge Univ. Press, 91-112. |
| بيانات النشر: | Cambridge Univ. Press |
| سنة النشر: | 2010 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Institute of Mathematics, 510 Mathematics |
| الوصف: | The dynamics of tumour evolution are not well understood. In this paper we provide a statistical framework for evaluating the molecular variation observed in different parts of a colorectal tumour. A multi-sample version of the Ewens Sampling Formula forms the basis for our modelling of the data, and we provide a simulation procedure for use in obtaining reference distributions for the statistics of interest. We also describe the large-sample asymptotics of the joint distributions of the variation observed in different parts of the tumour. While actual data should be evaluated with reference to the simulation procedure, the asymptotics serve to provide theoretical guidelines, for instance with reference to the choice of possible statistics. |
| نوع الوثيقة: | book part |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-521-14577-0 0-521-14577-5 |
| تدمد: | 0076-0552 |
| العلاقة: | https://www.zora.uzh.ch/id/eprint/36257/9/Assesing_molecular_variability_in_cancer_genomes.pdfTest; urn:isbn:978-0-5211-4577-0; urn:issn:0076-0552 |
| DOI: | 10.5167/uzh-36257 |
| الإتاحة: | https://doi.org/10.5167/uzh-36257Test https://www.zora.uzh.ch/id/eprint/36257Test/ https://www.zora.uzh.ch/id/eprint/36257/9/Assesing_molecular_variability_in_cancer_genomes.pdfTest http://www.cup.cam.ac.uk/catalogue/catalogue.asp?isbn=9780521145770Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.66DFBE3C |
| قاعدة البيانات: | BASE |
| ردمك: | 9780521145770 0521145775 |
|---|---|
| تدمد: | 00760552 |
| DOI: | 10.5167/uzh-36257 |