دورية أكاديمية
Structured lifestyle education for people with schizophrenia, schizoaffective disorder and first-episode psychosis (STEPWISE): randomised controlled trial
| العنوان: | Structured lifestyle education for people with schizophrenia, schizoaffective disorder and first-episode psychosis (STEPWISE): randomised controlled trial |
|---|---|
| المؤلفون: | Holt, RIG, Gossage-Worrall, R, Hind, D, Bradburn, MJ, McCrone, P, Morris, T, Edwardson, C, Barnard, K, Carey, ME, Davies, MJ, Dickens, CM, Doherty, Y, Etherington, A, French, P, Gaughran, F, Greenwood, KE, Kalidindi, S, Khunti, K, Laugharne, R, Pendlebury, J, Rathod, S, Saxon, D, Shiers, D, Siddiqi, N, Swaby, EA, Waller, G, Wright, S, Bradburn, M, Swaby, L, Davies, M, Carey, M, Northern, A, Barnett, J, Dickens, C, Greenwood, K |
| بيانات النشر: | CAMBRIDGE UNIV PRESS |
| سنة النشر: | 2019 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | BACKGROUND: Obesity is a major challenge for people with schizophrenia.AimsWe assessed whether STEPWISE, a theory-based, group structured lifestyle education programme could support weight reduction in people with schizophrenia. METHOD: In this randomised controlled trial (study registration: ISRCTN19447796), we recruited adults with schizophrenia, schizoaffective disorder or first-episode psychosis from ten mental health organisations in England. Participants were randomly allocated to the STEPWISE intervention or treatment as usual. The 12-month intervention comprised four 2.5 h weekly group sessions, followed by 2-weekly maintenance contact and group sessions at 4, 7 and 10 months. The primary outcome was weight change after 12 months. Key secondary outcomes included diet, physical activity, biomedical measures and patient-related outcome measures. Cost-effectiveness was assessed and a mixed-methods process evaluation was included. RESULTS: Between 10 March 2015 and 31 March 2016, we recruited 414 people (intervention 208, usual care 206) with 341 (84.4%) participants completing the trial. At 12 months, weight reduction did not differ between groups (mean difference 0.0 kg, 95% CI -1.6 to 1.7, P = 0.963); physical activity, dietary intake and biochemical measures were unchanged. STEPWISE was well-received by participants and facilitators. The healthcare perspective incremental cost-effectiveness ratio was £246 921 per quality-adjusted life-year gained. CONCLUSIONS: Participants were successfully recruited and retained, indicating a strong interest in weight interventions; however, the STEPWISE intervention was neither clinically nor cost-effective. Further research is needed to determine how to manage overweight and obesity in people with schizophrenia.Declaration of interestR.I.G.H. received fees for lecturing, consultancy work and attendance at conferences from the following: Boehringer Ingelheim, Eli Lilly, Janssen, Lundbeck, Novo Nordisk, Novartis, Otsuka, Sanofi, Sunovion, Takeda, MSD. M.J.D. reports ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0007-1250 1472-1465 |
| العلاقة: | pii: S0007125018001678; Holt, R. I. G., Gossage-Worrall, R., Hind, D., Bradburn, M. J., McCrone, P., Morris, T., Edwardson, C., Barnard, K., Carey, M. E., Davies, M. J., Dickens, C. M., Doherty, Y., Etherington, A., French, P., Gaughran, F., Greenwood, K. E., Kalidindi, S., Khunti, K., Laugharne, R. ,. Shiers, D. (2019). Structured lifestyle education for people with schizophrenia, schizoaffective disorder and first-episode psychosis (STEPWISE): randomised controlled trial. BRITISH JOURNAL OF PSYCHIATRY, 214 (2), pp.63-73. https://doi.org/10.1192/bjp.2018.167Test.; http://hdl.handle.net/11343/246221Test |
| الإتاحة: | https://doi.org/10.1192/bjp.2018.167Test http://hdl.handle.net/11343/246221Test |
| حقوق: | CC BY ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.F83E782F |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 00071250 14721465 |
|---|