دورية أكاديمية
Muscarinic antagonist effects on executive control of attention
| العنوان: | Muscarinic antagonist effects on executive control of attention |
|---|---|
| المؤلفون: | Thienel, R., Kellermann, T., Kircher, T., Schall, U., Voss, B., Reske, M., Halfter, S., Sheldrick, A.J., Radenbach, K., Habel, U., Shah, N.J. |
| المصدر: | The international journal of neuropsychopharmacology 12, 1307 - 1317 (2009). doi:10.1017/S146114570999068X |
| بيانات النشر: | Cambridge Univ. Press Cambridge Univ Press |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | info:eu-repo/classification/ddc/610, Adult, Attention: drug effects, Attention: physiology, Cross-Over Studies, Executive Function: drug effects, Executive Function: physiology, Humans, Male, Muscarinic Antagonists: pharmacology, Psychomotor Performance: drug effects, Psychomotor Performance: physiology, Reaction Time: drug effects, Reaction Time: physiology, Scopolamine Hydrobromide: pharmacology, Single-Blind Method, Young Adult, Muscarinic Antagonists, Scopolamine Hydrobromide, Anterior cingulate cortex, Attention Network Task, functional magnetic resonance imaging, scopolamine, verbal memory, psy |
| جغرافية الموضوع: | DE |
| الوصف: | Acetylcholine plays a major role in mediating attention processes. We investigated the muscarinic antagonist effect of scopolamine on functional neuro-anatomy of attention and cognition. We assessed 12 healthy volunteers while performing the Attention Network Task on 0.4 mg scopolamine and placebo in a single-blind randomized trial in a 1.5 T magnetic resonance scanner. Neurocognitive measures included verbal learning, verbal memory, verbal fluency, trail making, digit span, a continuous performance task and a planning task (Tower of London). When compared to placebo, scopolamine increased reaction times for conflicting stimulus processing, together with decreasing brain activation in the anterior cingulate cortex (a brain region involved in conflict processing) suggestive of a muscarinic antagonist effect on executive control of attention. Contrary to the notion of a predominantly right-hemispheric lateralization of cognitive processes associated with orienting attention, scopolamine reduced brain activity in left superior and left middle frontal brain areas. Our neuropsychological test data revealed a selective effect of scopolamine on verbal learning and memory while other cognitive domains, such as planning and working memory, were unaffected. These findings are consistent with muscarinic modulation of dopaminergic neurotransmission in frontal attention networks when processing conflicting information. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://juser.fz-juelich.de/record/20358Test |
| الإتاحة: | https://doi.org/10.1017/S146114570999068XTest https://juser.fz-juelich.de/record/20358Test |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.B3422A74 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |