دورية أكاديمية
Serial changes in plasma brain natriuretic peptide (BNP) concentration at the infarct and non-infarct sites in patients with left ventricular remodelling after myocardial infarction
| العنوان: | Serial changes in plasma brain natriuretic peptide (BNP) concentration at the infarct and non-infarct sites in patients with left ventricular remodelling after myocardial infarction |
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| المؤلفون: | Hirayama, Atsushi, Kusuoka, Hideo, Yamamoto, Hiroyoshi, Sakata, Yasushi, Asakura, Masanori, Higuchi, Yoshiharu, Mizuno, Hiroya, Kashiwase, Kazunori, Ueda, Yasunori, Okuyama, Yuji, Hori, Masatsugu, Kodama, Kazuhisa |
| بيانات النشر: | British Medical Journal Publishing Group |
| سنة النشر: | 2005 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Original articles |
| الوصف: | Objectives : To clarify the role of infarct and non-infarct sites on left ventricular (LV) remodeling after myocardial infarction (MI) by the measurement of brain natriuretic peptide (BNP) from each site. Methods and results : BNP from the aorta (A) and the anterior interventricular vein (AIV) was measured in 45 patients with first anterior MI at 1, 6, and 18 months. Significant dilatation of LV (>10 ml/m2 of end-diastolic volume from 1 to 18 months) was observed in 20 patients (group R), but not in 25 others (group NR). Patient characteristics and LV functions did not differ significantly at 1 month, but plasma BNP concentration was higher in group R than in group NR (336±288 vs. 116±106 pg/ml; p<0.01), predicting the degree of LV dilatation. The difference in BNP concentration between A and AIV (ΔBNP), reflecting BNP secreted from the infarct site, did not differ at 1 month. In both groups BNP and ΔBNP significantly decreased from 1 to 6 months (p<0.05), and decreased from 6 months to 18 months but the change was not significant. Although BNP and ΔBNP were significantly higher in group R than NR after 6 months, when LV dilatation was not evident in both groups. Conclusion : Enhanced BNP secretion at 1 month in the non-infarct and the infarct ventricular sites predicts the subsequent LV dilatation (i.e. remodeling). The slower process of LV remodeling decreased BNP secretion at both sites. Thus, BNP concentration should be useful for monitoring ventricular remodeling after infarction. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://heart.bmj.com/cgi/content/short/hrt.2004.049635v1Test; http://dx.doi.org/10.1136/hrt.2004.049635Test |
| DOI: | 10.1136/hrt.2004.049635 |
| الإتاحة: | https://doi.org/10.1136/hrt.2004.049635Test http://heart.bmj.com/cgi/content/short/hrt.2004.049635v1Test |
| حقوق: | Copyright (C) 2005, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.84503314 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/hrt.2004.049635 |
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