دورية أكاديمية
Calcium and vitamin D supplementation in underprivileged indian toddlers using enriched 'ladoos'
| العنوان: | Calcium and vitamin D supplementation in underprivileged indian toddlers using enriched 'ladoos' |
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| المؤلفون: | Ekbote, V, Khadilkar, A, Chiplonkar, S, Hanumante, N, Khadilkar, V, Mughal, MZ |
| بيانات النشر: | British Medical Journal Publishing Group |
| سنة النشر: | 2010 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | British Society for Paediatric Endocrinology and Diabetes/British Paediatric and Adolescent Bone Group |
| الوصف: | Vitamin D deficiency is common among children in India, in spite of abundance in sunshine. Calcium intake among such children is often low. These children might benefit from calcium and vitamin D supplementation; however, oral pharmacological preparations of these nutrients are often unpalatable. The authors used “Ladoo”, a much cherished Indian sweet, as a novel vehicle for administering calcium and vitamin D supplements. Toddlers from an urban slum in Pune, India, with low dietary calcium intake (<200 mg/day) were randomised to a daily ration of a calcium enriched Ladoo containing, 700 mg elemental calcium (n=30; 2.9±0.5 years), or a control Ladoo , containing 170 mg of elemental calcium (n=30; 2.6±0.5 years), for one year. Subjects in both groups also ate a Ladoo supplemented with 30.000 i.u. of Cholecalciferol, once a month, during the trial. The main outcome measure was the increment in size adjusted total body bone mineral content (TBMC), measured using the GE-Lunar DPX Pro dual energy x-ray absorptiometry. Serum concentration of 25-hydroxy vitamin D in the calcium enriched Ladoo group increased from 25±27 nmol/l to 40±39 nmol/l, and in the control group from 25±27 nmol/l to 39±27 nmol/l. At the end of the trial the change in serum ionised calcium concentration in the calcium enriched Ladoo group (+0.14±0.23 mmol/l) was greater (p=0.004) than in the control group (−0.07±0.19). Serum parathyroid hormone concentration and alkaline phosphatase activity fell in the both groups; however, the change was not statistically different between the groups. The increment in size adjusted TBMC in the calcium enriched Ladoo group was greater (p<0.05) than in the control group. From these results we conclude that monthly consumption of a cholecalciferol fortified Ladoo can be used to improve the vitamin D status of underprivileged Indian toddlers. Daily consumption of a calcium fortified Ladoo has the potential of improving skeletal mineralisation of toddlers with low dietary calcium intake. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://adc.bmj.com/cgi/content/short/95/1_MeetingAbstracts/A92Test; http://dx.doi.org/10.1136/adc.2010.186338.200Test |
| DOI: | 10.1136/adc.2010.186338.200 |
| الإتاحة: | https://doi.org/10.1136/adc.2010.186338.200Test http://adc.bmj.com/cgi/content/short/95/1_MeetingAbstracts/A92Test |
| حقوق: | Copyright (C) 2010, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.19E11745 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/adc.2010.186338.200 |
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