دورية أكاديمية
Cost-effectiveness of cardiac resynchronisation therapy for patients with moderate-to-severe heart failure: a lifetime Markov model
| العنوان: | Cost-effectiveness of cardiac resynchronisation therapy for patients with moderate-to-severe heart failure: a lifetime Markov model |
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| المؤلفون: | Neyt, Mattias, Stroobandt, Serge, Obyn, Caroline, Camberlin, Cécile, Devriese, Stephan, De Laet, Chris, Van Brabandt, Hans |
| بيانات النشر: | British Medical Journal Publishing Group |
| سنة النشر: | 2011 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Research |
| الوصف: | Objective To assess the cost-effectiveness of cardiac resynchronisation therapy (CRT) both with CRT-P (biventricular pacemaker only) and with CRT-D (biventricular pacemaker with defibrillator) in patients with New York Heart Association (NYHA) functional class III/IV from a Belgian healthcare-payer perspective. Methods A lifetime Markov model was designed to calculate the cost–utility of both interventions. In the reference case, the treatment effect was based on the Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure trial. Costs were based on real-world data. Pharmacoeconomic guidelines were applied, including probabilistic modelling and sensitivity analyses. Results Compared with optimal medical treatment, on average 1.31 quality-adjusted life-years (QALY) are gained with CRT-P at an additional cost of €14 700, resulting in an incremental cost-effectiveness ratio (ICER) of about €364;11 200/QALY. As compared with CRT-P, CRT-D treatment adds on average an additional 0.55 QALYs at an extra cost of €30 900 resulting in an ICER of €57 000/QALY. This result was very sensitive to the incremental clinical benefit of the defibrillator function on top of CRT. Conclusions Based on efficiency arguments, CRT-P can be recommended for NYHA class III and IV patients if there is a willingness to pay more than €11 000/QALY. Even though CRT-D may offer a survival benefit over CRT-P, the incremental clinical benefit appears to be too marginal to warrant a threefold-higher device price for CRT-D. Further clinical research should focus on the added value of CRT-D over CRT-P. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://bmjopen.bmj.com/cgi/content/short/1/2/e000276Test; http://dx.doi.org/10.1136/bmjopen-2011-000276Test |
| DOI: | 10.1136/bmjopen-2011-000276 |
| الإتاحة: | https://doi.org/10.1136/bmjopen-2011-000276Test http://bmjopen.bmj.com/cgi/content/short/1/2/e000276Test |
| حقوق: | Copyright (C) 2011, British Medical Journal Publishing Group |
| رقم الانضمام: | edsbas.E2C01E3E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmjopen-2011-000276 |
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