دورية أكاديمية
Brain metastases from primary colorectal cancer: Is radiosurgery an effective treatment approach? Results of a multicenter study of the radiation and clinical oncology Italian association (AIRO)
| العنوان: | Brain metastases from primary colorectal cancer: Is radiosurgery an effective treatment approach? Results of a multicenter study of the radiation and clinical oncology Italian association (AIRO) |
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| المؤلفون: | Navarria P., Minniti G., Clerici E., Comito T., Cozzi S., Pinzi V., Fariselli L., Ciammella P., Scoccianti S., Borzillo V., Anselmo P., Maranzano E., Dell'Acqua V., Jereczek-Fossa B., Levra N. G., Podlesko A. M., Giudice E., Di Monale E Bastia M. B., Pedretti S., Bruni A., Zanetti I. B., Borghesi S., Busato F., Pasqualetti F., Paiar F., Scorsetti M. |
| المساهمون: | P. Navarria, G. Minniti, E. Clerici, T. Comito, S. Cozzi, V. Pinzi, L. Fariselli, P. Ciammella, S. Scoccianti, V. Borzillo, P. Anselmo, E. Maranzano, V. Dell'Acqua, B. Jereczek-Fossa, N.G. Levra, A.M. Podlesko, E. Giudice, M.B. Di Monale E Bastia, S. Pedretti, A. Bruni, I.B. Zanetti, S. Borghesi, F. Busato, F. Pasqualetti, F. Paiar, M. Scorsetti |
| بيانات النشر: | British Institute of Radiology |
| سنة النشر: | 2020 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Adult, Aged, 80 and over, Brain Neoplasm, Colorectal Neoplasm, Female, Human, Italy, Male, Medical Oncology, Middle Aged, Retrospective Studie, Societies, Medical, Treatment Outcome, Radiosurgery, Settore MED/36 - Diagnostica per Immagini e Radioterapia |
| الوصف: | Objectives: The prognosis of brain metastatic colorectal cancer patients (BMCRC) is poor. Several local treatments have been used, but the optimal treatment choice remains an unresolved issue. We evaluated the clinical outcomes of a large series of BMCRC patients treated in several Italian centers using stereotactic radiosurgery (SRS). Methods: 185 BMCRC patients for a total of 262 lesions treated were evaluated. Treatments included surgery followed by post-operative SRS to the resection cavity, and SRS, either single-fraction, then hypofractionated SRS (HSRS). Outcomes was measured in terms of local control (LC), toxicities, brain distant failure (BDF), and overall survival (OS). Prognostic factors influencing survival were assed too. Results: The median follow-up time was 33 months (range 3-183 months). Surgery plus SRS have been performed in 28 (10.7%) cases, SRS in 141 (53.8%), and HSRS in 93 (35.5%). 77 (41.6%) patients received systemic therapy. The main total dose and fractionation used were 24Gy in single fraction or 24Gy in three daily fractions. Local recurrence occurred in 32 (17.3%) patients. Median, 6 months,1-year-LC were 86 months (95%CI 36-86), 87.2% ± 2.8, 77.8% ± 4.1. Median,6 months,1-year-BDF were 23 months (95%CI 9-44), 66.4% ± 3.9, 55.3% ± 4.5. Median,6 months,1-year-OS were 7 months (95%CI 6-9), 52.7% ± 3.6, 33% ± 3.5. No severe neurological toxicity occurred. Stage at diagnosis, Karnofsky Performance Status (KPS), presence and number of extracranial metastases, and disease-specific-graded-prognostic-assessment (DS-GPA) score were observed as conditioning survival. Conclusion: SRS/HSRS have proven to be an effective local treatment for BMCRC. A careful evaluation of prognostic factors as well as a multidisciplinary evaluation is a valid aid to manage the optimal therapeutic strategy for CTC patients with BMs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/33035077; info:eu-repo/semantics/altIdentifier/wos/WOS:000592669400024; volume:93; issue:1116; firstpage:1; lastpage:10; numberofpages:10; journal:BRITISH JOURNAL OF RADIOLOGY; http://hdl.handle.net/2434/907234Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85096509149 |
| DOI: | 10.1259/bjr.20200951 |
| الإتاحة: | https://doi.org/10.1259/bjr.20200951Test http://hdl.handle.net/2434/907234Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.80AE8FB9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1259/bjr.20200951 |
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