Comparison of two radiation techniques for the breast boost in patients undergoing neoadjuvant treatment for breast cancer
| العنوان: | Comparison of two radiation techniques for the breast boost in patients undergoing neoadjuvant treatment for breast cancer |
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| المؤلفون: | Vincenzo Valentini, Luigia Nardone, Michela Dispinzieri, Laura Lozza, R. Canna, Maria Carmen De Santis, Barbara Diletto, Lorenza Marino |
| المصدر: | The British Journal of Radiology. 89:20160264 |
| بيانات النشر: | British Institute of Radiology, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, medicine.medical_treatment, Breast Neoplasms, Mastectomy, Segmental, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Nuclear Medicine and Imaging, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, Radiometry, Neoadjuvant therapy, Aged, Neoplasm Staging, Retrospective Studies, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Chemotherapy, Full Paper, business.industry, Radiotherapy Planning, Computer-Assisted, Dose fractionation, Heart, Radiotherapy Dosage, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Neoadjuvant Therapy, Radiation therapy, Treatment Outcome, 030220 oncology & carcinogenesis, Female, Dose Fractionation, Radiation, Neoplasm Grading, Tomography, X-Ray Computed, Radiology, Nuclear medicine, business, Mastectomy |
| الوصف: | After breast conservative surgery (BCS) and whole-breast radiotherapy (WBRT), the use of boost irradiation is recommended especially in patients at high risk. However, the standard technique and the definition of the boost volume have not been well defined.We retrospectively compared an anticipated pre-operative photon boost on the tumour, administered with low-dose fractionated radiotherapy, and neoadjuvant chemotherapy with two different sequential boost techniques, administered after BCS and standard adjuvant WBRT: (1) a standard photon beam (2) and an electron beam technique on the tumour bed of the same patients. The plans were analyzed for the dosimetric coverage of the CT-delineated irradiated volume. The minimal dose received by 95% of the target volume (D95), the minimal dose received by 90% of the target volume (D90) and geographic misses were evaluated.15 patients were evaluated. The sequential photon and electron boost techniques resulted in inferior target volume coverage compared with the anticipated boost technique, with a median D95 of 96.3% (range 94.7-99.6%) and 0.8% (range 0-30%) and a median D90 of 99.1% (range 90.2-100%) and 54.7% (range 0-84.8%), respectively. We observed a geographic miss in 26.6% of sequential electron plans. The results of the anticipated boost technique were better: 99.4% (range 96.5-100%) and 97.1% (range 86.2-99%) for median D90 and median D95, respectively, and no geographic miss was observed. We observed a dose reduction to the heart, with left-sided breast irradiation, using the anticipated pre-operative boost technique, when analyzed for all dose-volume parameters. When compared with the sequential electron plans, the pre-operative photon technique showed a higher median ipsilateral lung Dmax.Our data show that an anticipated pre-operative photon boost results in a better coverage with respect to the standard sequential boost while also saving the organs at risk and consequently fewer side effects.This is the first dosimetric study that evaluated the association between an anticipated boost and neoadjuvant chemotherapy treatment. |
| تدمد: | 1748-880X 0007-1285 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d32126ba2184c68885f5c1887b7164Test https://doi.org/10.1259/bjr.20160264Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....14d32126ba2184c68885f5c1887b7164 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1748880X 00071285 |
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