مورد إلكتروني
Plasmodium falciparum Plasmepsins IX and X: Structure- Function Analysis and the Discovery of New Lead Antimalarial drugs
| العنوان: | Plasmodium falciparum Plasmepsins IX and X: Structure- Function Analysis and the Discovery of New Lead Antimalarial drugs |
|---|---|
| بيانات النشر: | Griffith University Brisbane 2014 |
| تفاصيل مُضافة: | Skinner-Adams, Tina Brown, Chris Gardiner, Donald McGeorge, Rachael Dawn |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Full Text Thesis (PhD Doctorate) Doctor of Philosophy (PhD) School of Biomolecular and Physical Sciences Science, Environment, Engineering and Technology Malaria is a deadly parasitic infection that poses an enormous threat to global health. While drugs are available, all of our current antimalarials are being gradually rendered ineffective by spreading drug resistance. Reports of increasing tolerance to artemisinin combination therapies, our most potent antimalarial treatments, are particularly concerning. To combat this problem there is an urgent need to identify new and unique targets within the malaria parasite against which novel chemotherapeutics can be developed. Studies investigating the antimalarial activity of HIV protease inhibitors (HIV PIs) have shown that these drugs can inhibit the growth of Plasmodium in vitro, in vivo and ex vivo at clinically relevant concentrations. While the anti-parasitic action of these drugs is not fully understood, it is believed these agents inhibit the growth of parasites by targeting an essential malarial aspartic protease or plasmepsin (PM) and that these enzymes may represent new targets for drug development. The aim of this thesis was to investigate the Plasmodium falciparum aspartic proteases PM IX and X as potential new targets for antimalarial development. |
| مصطلحات الفهرس: | Malaria, Anti-malarial drugs, Plasmodium falciparum Plasmepsins IX and X, Griffith thesis |
| الإتاحة: | Open access content. Open access content The author owns the copyright in this thesis, unless stated otherwise. Public The author owns the copyright in this thesis, unless stated otherwise. |
| ملاحظة: | application/pdf English |
| أرقام أخرى: | LG0 oai:research-repository.griffith.edu.au:10072/365553 10.25904/1912/610 1327828064 |
| المصدر المساهم: | GRIFFITH UNIV From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1327828064 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |