دورية أكاديمية
Relationship between neuromelanin and dopamine terminals within the Parkinson's nigrostriatal system.
| العنوان: | Relationship between neuromelanin and dopamine terminals within the Parkinson's nigrostriatal system. |
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| المؤلفون: | Martín-Bastida, Antonio, Lao-Kaim, Nicholas P, Roussakis, Andreas Antonios, Searle, Graham E, Xing, Yue, Gunn, Roger N, Schwarz, Stefan T, Barker, Roger A, Auer, Dorothee P, Piccini, Paola |
| بيانات النشر: | //dx.doi.org/10.1093/brain/awz120 Brain Oxford University Press (OUP) |
| سنة النشر: | 2019 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | Parkinson’s disease, dopamine transporter, magnetic resonance imaging, neuromelanin, positron emission tomography, Case-Control Studies, Corpus Striatum, Cross-Sectional Studies, Dopamine, Female, Humans, Male, Melanins, Middle Aged, Nerve Endings, Neuroimaging, Nortropanes, Positron-Emission Tomography, Substantia Nigra |
| الوصف: | Parkinson's disease is characterized by the progressive loss of pigmented dopaminergic neurons in the substantia nigra and associated striatal deafferentation. Neuromelanin content is thought to reflect the loss of pigmented neurons, but available data characterizing its relationship with striatal dopaminergic integrity are not comprehensive or consistent, and predominantly involve heterogeneous samples. In this cross-sectional study, we used neuromelanin-sensitive MRI and the highly specific dopamine transporter PET radioligand, 11C-PE2I, to assess the association between neuromelanin-containing cell levels in the substantia nigra pars compacta and nigrostriatal terminal density in vivo, in 30 patients with bilateral Parkinson's disease. Fifteen healthy control subjects also underwent neuromelanin-sensitive imaging. We used a novel approach taking into account the anatomical and functional subdivision of substantia nigra into dorsal and ventral tiers and striatal nuclei into pre- and post-commissural subregions, in accordance with previous animal and post-mortem studies, and consider the clinically asymmetric disease presentation. In vivo, Parkinson's disease subjects displayed reduced neuromelanin levels in the ventral (-30 ± 28%) and dorsal tiers (-21 ± 24%) as compared to the control group [F(1,43) = 11.95, P = 0.001]. Within the Parkinson's disease group, nigral pigmentation was lower in the ventral tier as compared to the dorsal tier [F(1,29) = 36.19, P < 0.001] and lower in the clinically-defined most affected side [F(1,29) = 4.85, P = 0.036]. Similarly, lower dopamine transporter density was observed in the ventral tier [F(1,29) = 76.39, P < 0.001] and clinically-defined most affected side [F(1,29) = 4.21, P = 0.049]. Despite similar patterns, regression analysis showed no significant association between nigral pigmentation and nigral dopamine transporter density. However, for the clinically-defined most affected side, significant relationships were observed between pigmentation of the ventral ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print; application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document; image/tiff |
| اللغة: | English |
| العلاقة: | https://www.repository.cam.ac.uk/handle/1810/290591Test |
| DOI: | 10.17863/CAM.37818 |
| الإتاحة: | https://doi.org/10.17863/CAM.37818Test https://www.repository.cam.ac.uk/handle/1810/290591Test |
| رقم الانضمام: | edsbas.BD7B4189 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.37818 |
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