دورية أكاديمية
The bone marrow microenvironment is similarly impaired in allogeneic hematopoietic stem cell transplantation patients with early and late poor graft function
| العنوان: | The bone marrow microenvironment is similarly impaired in allogeneic hematopoietic stem cell transplantation patients with early and late poor graft function |
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| المؤلفون: | Kong, Y., Wang, Y-T, Hu, Y., Han, W., Chang, Y-J, Zhang, X-H, Jiang, Z-F, Huang, X-J |
| المساهمون: | Huang, XJ (reprint author), Peking Univ, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Collaborat Innovat Ctr Hematol, Peoples Hosp,Inst Hematol, Beijing 100044, Peoples R China., Peking Univ, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Collaborat Innovat Ctr Hematol, Peoples Hosp,Inst Hematol, Beijing 100044, Peoples R China., Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100044, Peoples R China., Peking Univ, Sch Life Sci, Key Lab Cell Proliferat & Differentiat, Minist Educ, Beijing 100044, Peoples R China. |
| المصدر: | SCI ; PubMed |
| بيانات النشر: | BONE MARROW TRANSPLANTATION |
| سنة النشر: | 2016 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | VERSUS-HOST-DISEASE, RISK STRATIFICATION, NICHE, FAILURE, ASSOCIATION, RECOVERY, LEUKEMIA, REDUCE, BLOOD, BOOST |
| الوصف: | Poor graft function (PGF), including early and late PGF, is a serious complication following allotransplant. We recently reported that bone marrow microenvironment abnormalities may occur in cases of late PGF. Whether these abnormalities occur in early PGF remains unknown. To answer this question, we performed a nested case-control study comparing cellular elements of the bone marrow microenvironment in 10 subjects with early PGF, 30 subjects with late PGF and 40 subjects without PGF. Bone marrow endosteal cells, perivascular cells and endothelial cells were analyzed by flow cytometry and by hematoxylin-eosin and immunohistochemical staining in situ. Subjects with early and late PGF had similar abnormalities in these cell types compared with transplant recipients without PGF. However, none of the aforementioned elements of the bone marrow microenvironment were significantly different between early and late PGF patients. Our data suggest that similar abnormalities in the bone marrow microenvironment may occur in early and late PGF post allotransplant. Cellular approaches, such as the administration of mesenchymal stem cells, promise to be beneficial therapeutic strategies in patients with early or late PGF. ; National Natural Science Foundation of China [81370638, 81570127, 81530046, 81230013]; Beijing Municipal Science and Technology Program [Z151100004015164, Z151100001615020, Z141100000214011]; National High Technology Research Development Program of China [SS2013AA020104] ; SCI(E) ; PubMed ; ARTICLE ; huangxiaojun@bjmu.edu.cn ; 2 ; 249-255 ; 51 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0268-3369 1476-5365 26437066 |
| العلاقة: | BONE MARROW TRANSPLANTATION.2016,51,(2),249-255.; 1296165; http://hdl.handle.net/20.500.11897/417687Test; WOS:000369100700016 |
| DOI: | 10.1038/bmt.2015.229 |
| الإتاحة: | https://doi.org/20.500.11897/417687Test https://doi.org/10.1038/bmt.2015.229Test https://hdl.handle.net/20.500.11897/417687Test |
| رقم الانضمام: | edsbas.1EF632FB |
| قاعدة البيانات: | BASE |
| تدمد: | 02683369 14765365 26437066 |
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| DOI: | 10.1038/bmt.2015.229 |