دورية أكاديمية
Effects of alpha interferon induction plus ribavirin with or without amantadine in the treatment of interferon non-responsive chronic hepatitis C: a randomised trial
| العنوان: | Effects of alpha interferon induction plus ribavirin with or without amantadine in the treatment of interferon non-responsive chronic hepatitis C: a randomised trial |
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| المؤلفون: | Adinolfi, L E, Utili, R, Tonziello, A, Ruggiero, G |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 2003 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Liver |
| الوصف: | Background: Fifty per cent of chronic hepatitis C patients are non-responders to interferon. At present, there are no recommended therapeutic options for non-responders. Aims: The safety and long term effect of alpha interferon induction plus ribavirin with or without amantadine in the treatment of interferon non-responsive chronic hepatitis C was evaluated. Patients and methods: A total of 114 consecutive patients were randomly divided into three groups with a final 2:2:1 ratio: group A (44 patients) received interferon alfa 2b, 3 million units (MU), three times a week, and oral ribavirin (1000 mg/day); group B (46 patients) received interferon 3 MU daily for the first four weeks and subsequently 3 MU three times a week, and ribavirin as in regimen A; and group C (24 patients) received interferon and ribavirin as in regimen B, plus oral amantadine hydrochloride (200 mg/day). The duration of treatment was 12 months. Results: The end of treatment response for groups A and B was 25% and 29%, respectively, and for group C, 68% (p<0.005). At the end of one year of follow up, a sustained response was observed for six (25%) patients in group C, one (2%) patient in group A, and two (4%) patients in group B (p<0.002). The triple regimen was well tolerated and did not increase the frequency or severity of side effects. Conclusions: The study demonstrates that for the treatment of interferon non-responder hepatitis C patients, the association of interferon-ribavirin has a negligible long term effect whereas a triple regimen including interferon, ribavirin, and amantadine can be an effective and safe treatment. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://gut.bmj.com/cgi/content/short/52/5/701Test; http://dx.doi.org/10.1136/gut.52.5.701Test |
| DOI: | 10.1136/gut.52.5.701 |
| الإتاحة: | https://doi.org/10.1136/gut.52.5.701Test http://gut.bmj.com/cgi/content/short/52/5/701Test |
| حقوق: | Copyright (C) 2003, BMJ Publishing Group |
| رقم الانضمام: | edsbas.5413A3DF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/gut.52.5.701 |
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