دورية أكاديمية
Abrupt cessation of short-term continuous treatment with isosorbide dinitrate may cause a rebound increase in silent myocardial ischaemia in patients with stable angina pectoris.
| العنوان: | Abrupt cessation of short-term continuous treatment with isosorbide dinitrate may cause a rebound increase in silent myocardial ischaemia in patients with stable angina pectoris. |
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| المؤلفون: | Martsevich, S. Y., Koutishenko, N., Metelitsa, V. I. |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 1996 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Research Article |
| الوصف: | OBJECTIVE: To examine by Holter electrocardiographic monitoring the effect of abruptly stopping nitrate treatment in patients with stable angina pectoris. PATIENTS: 12 men with confirmed ischaemic heart disease and stable exertional class 3 angina (Canadian). All had episodes of horizontal or down sloping ST segment depression during 24 hour electrocardiographic monitoring. All were nitrate responders. DESIGN: Each patient was given isosorbide dinitrate (10-30 mg four times a day) and placebo (four times a day) for three days in a randomised crossover trial. There was a washout period of 3-5 days between the two treatment periods. Holter monitoring was performed on the third day of isosorbide dinitrate and placebo administration and on the first day of their withdrawal. RESULTS: When treatment with isosorbide dinitrate was stopped there was a significant increase in the total number and duration of painless episodes of myocardial ischaemia. During placebo and isosorbide dinitrate administration 8 patients had episodes of painless myocardial ischaemia whereas after isosorbide dinitrate cessation they were recorded in all 12 patients. Episodes of silent myocardial ischaemia at rest appeared in 4 patients after isosorbide dinitrate withdrawal. CONCLUSION: Abrupt cessation of short-term continuous nitrate treatment in patients with severe angina may cause a rebound increase in myocardial ischaemia which is predominantly silent. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://heart.bmj.com/cgi/content/short/75/5/447Test; http://dx.doi.org/10.1136/hrt.75.5.447Test |
| DOI: | 10.1136/hrt.75.5.447 |
| الإتاحة: | https://doi.org/10.1136/hrt.75.5.447Test http://heart.bmj.com/cgi/content/short/75/5/447Test |
| حقوق: | Copyright (C) 1996, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.856E0DBF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/hrt.75.5.447 |
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