دورية أكاديمية
Itraconazole as 'bridge therapy' to anti-IgE in a patient with severe asthma with fungal sensitisation
| العنوان: | Itraconazole as 'bridge therapy' to anti-IgE in a patient with severe asthma with fungal sensitisation |
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| المؤلفون: | Pizzimenti, Stefano, Bussolino, Claudia, Badiu, Iuliana, Rolla, Giovanni |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 2013 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | case-report |
| الوصف: | Sensitisation to fungi has been reported to play an important role in a particular phenotype of severe asthma, the so-called severe asthma with fungal sensitisation, characterised by high levels of total IgE, which may be an obstacle to anti-IgE therapy. We describe here the case of a polysensitised woman with refractory asthma, sensitised to Aspergillus fumigatus with high total IgE values (1793 kUA/l), but without the diagnostic criteria for allergic bronchopulmonary aspergillosis. Additional therapy with itraconazole leads to the decrease of total IgE to the limits recommended for proper omalizumab dosing (30–1500 kUA/l). Itraconazole, used as bridge therapy, provided us the opportunity to start anti-IgE treatment in a patient with high levels of total IgE, beyond the upper limits recommended for proper prescription of omalizumab. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://casereports.bmj.com/cgi/content/short/2013/apr17_1/bcr2012008462Test; http://dx.doi.org/10.1136/bcr-2012-008462Test |
| DOI: | 10.1136/bcr-2012-008462 |
| الإتاحة: | https://doi.org/10.1136/bcr-2012-008462Test http://casereports.bmj.com/cgi/content/short/2013/apr17_1/bcr2012008462Test |
| حقوق: | Copyright (C) 2013, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.DEA271BB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bcr-2012-008462 |
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