دورية أكاديمية
Gut microbiota associated with HIV infection is significantly enriched in bacteria tolerant to oxygen
| العنوان: | Gut microbiota associated with HIV infection is significantly enriched in bacteria tolerant to oxygen |
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| المؤلفون: | Dubourg, Gregory, Lagier, Jean-Christophe, J.-C., Hue, Sophie, Surénaud, Mathieu, Bachar, Dipankar, Robert, Catherine, Michelle, Caroline, Ravaux, Isabelle, Mokhtari, Saadia, Million, Matthieu, Stein, Andreas, Brouqui, Philippe, Levy, Yves, Raoult, Didier |
| المساهمون: | Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, Institut des sciences biologiques - CNRS Biologie (INSB-CNRS)-Institut des sciences biologiques - CNRS Biologie (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Epidémiologie et Biostatistique Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Cochin (UMR_S567 / UMR 8104), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de signalisation, biologie du développement et cancer - Institute of Developmental Biology and Cancer (IBDC), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA), Service des Maladies Infectieuses et Tropicales Hôpital de la Conception (SMIT), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Conception CHU - APHM (LA CONCEPTION), Service des Maladies Infectieuses et Tropicales CHU Hôpital Nord - Marseille (M.I.T), Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital Nord CHU - APHM, Maladies Infectieuses et Tropicales (MIT), Service d'immunologie clinique Créteil, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12) |
| المصدر: | ISSN: 2054-4774 ; BMJ Open Gastroenterology ; https://amu.hal.science/hal-01787250Test ; BMJ Open Gastroenterology, 2016, 3 (1), ⟨10.1136/bmjgast-2016-000080⟩. |
| بيانات النشر: | HAL CCSD BMJ Publishing Group |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology |
| الوصف: | International audience ; Objectives Gut microbiota modifications occurring during HIV infection have recently been associated with inflammation and microbial translocation. However, discrepancies between studies justified a comprehensive analysis performed on a large sample size.Design and methods In a case–control study, next-generation sequencing of the 16S rRNA gene was applied to the faecal microbiota of 31 HIV-infected patients, of whom 18 were treated with antiretroviral treatment (ART), compared with 27 healthy controls. 21 sera samples from HIV-infected patients and 7 sera samples from control participants were used to test the presence of 25 markers of inflammation and/or immune activation.Results Diversity was significantly reduced in HIV individuals when compared with controls and was not restored in the ART group. The relative abundance of several members of Ruminococcaceae such as Faecalibacterium prausnitzii was critically less abundant in the HIV-infected group and inversely correlated with inflammation/immune activation markers. Members of Enterobacteriaceae and Enterococcaceae were found to be enriched and positively correlated with these markers. There were significantly more aerotolerant species enriched in HIV samples (42/52 species, 80.8%) when compared with the control group (14/87 species, 16.1%; χ2 test, p<10−5, conditional maximum-likelihood estimate (CMLE) OR=21.9).Conclusions Imbalance between aerobic and anaerobic flora observed in HIV faecal microbiota could be a consequence of the gut impairment classically observed in HIV infection via the production of oxygen. Overgrowth of proinflammatory aerobic species during HIV infection raises the question of antioxidant supplementation, such as vitamin C, E or N-acetylcysteine. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-01787250; https://amu.hal.science/hal-01787250Test; https://amu.hal.science/hal-01787250/documentTest; https://amu.hal.science/hal-01787250/file/e000080.full.pdfTest |
| DOI: | 10.1136/bmjgast-2016-000080 |
| الإتاحة: | https://doi.org/10.1136/bmjgast-2016-000080Test https://amu.hal.science/hal-01787250Test https://amu.hal.science/hal-01787250/documentTest https://amu.hal.science/hal-01787250/file/e000080.full.pdfTest |
| حقوق: | http://creativecommons.org/licenses/by-ncTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.82146444 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/bmjgast-2016-000080 |
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