Alcohol intake and the risk of coronary heart disease in the Spanish EPIC
| العنوان: | Alcohol intake and the risk of coronary heart disease in the Spanish EPIC |
|---|---|
| المؤلفون: | Arriola, L, Martinez-Camblor, P, Larrañaga, N, Basterretxea, M, Amiano, P, Moreno-Iribas, C, Carracedo, R, Agudo, A, Ardanaz, E, Barricarte, A, Buckland, G, Cirera, L, Chirlaque, M D, Martínez, C, Molina, E, Navarro, C, Quirós, J R, Rodríguez, L, Sánchez, M J, Tormo, M J, González, C A, Dorronsoro, M |
| المساهمون: | [Arriola, L, Martinez-Camblor, P, Larranaga, N, Basterretxea, M, Amiano, P, Carracedo, R, Dorronsoro, M.] Basque Govt, Publ Hlth Dept Gipuzkoa, San Sebastian, Spain. [Arriola, L, Moreno-Iribas, C, Ardanaz, E, Barricarte, A, Cirera, L, Chirlaque, MD, Martinez, C, Molina, E, Navarro, C, Sanchez, M. J, Tormo, M. J, Dorronsoro, M.] CIBERESP, Barcelona, Spain. [Agudo, A, Buckland, G, Gonzalez, C. A.] Catalan Inst Oncol ICO, Canc Epidemiol Res Programme, Unit Nutr Environm & Canc, Barcelona, Spain. [Moreno-Iribas, C, Barricarte, A.] Publ Hlth Inst Navarra, Pamplona, Spain. [Cirera, L, Chirlaque, M. D, Tormo, M. J.] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain. [Martinez, C, Sanchez, M. J.] Andalusian Sch Publ Hlth, Granada, Spain. [Quiros, J. R, Rodriguez, L.] Publ Hlth & Hlth Planning Directorate, Asturias, Spain. [Moreno-Iribas, C] UAB, Dept Paediat Obstet & Gynaecol & Prevent Med, Doctoral Degree Programme, Barcelona, Spain., This work was supported by grants from the Spanish Ministry of Health (FIS PI04/0104, PI04/1644, PI04/1822, PI04/2342, PI04/2188 and PI06/0365) and CIBERESP. The EPIC study received financial support from the European Commission (agreement SO 97 200302 05F02), the participating Regional Governments, the Red Temática de Investigación Cooperativa de Centros de Cáncer (RTICCC, C03/10) and the International Agency for Research on Cancer (agreement AEP/93/02). |
| بيانات النشر: | BMJ Publishing Group, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Estudio multicéntrico, Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies [Medical Subject Headings], Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], Publication Characteristics::Study Characteristics::Multicenter Study [Medical Subject Headings], Enfermedad coronaria, España, Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking [Medical Subject Headings], Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Causality::Risk Factors [Medical Subject Headings], Consumo de Bebidas alcohólicas, Diseases::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Coronary Disease [Medical Subject Headings], Factores de riesgo |
| الوصف: | Background: The association between alcohol consumption and coronary heart disease (CHD) has been widely studied. Most of these studies have concluded that moderate alcohol intake reduces the risk of CHD. There are numerous discussions regarding whether this association is causal or biased. The objective of this paper is to analyse the association between alcohol intake and CHD risk in the Spanish cohort of the European Prospective Investigation into Cancer (EPIC). Methods: Participants from the EPIC Spanish cohort were included (15 630 men and 25 808 women). The median follow-up period was 10 years. Ethanol intake was calculated using a validated dietary history questionnaire. Participants with a definite CHD event were considered cases. A Cox regression model adjusted for relevant co-variables and stratified by age was produced. Separate models were carried out for men and women. Results: The crude CHD incidence rate was 300.6/100 000 person-years for men and 47.9/100 000 person-years for women. Moderate, high and very high consumption was associated with a reduced risk of CHD in men: hazard ratio 0.90 (95% CI 0.56 to 1.44) for former drinkers, 0.65 (95% CI 0.41 to 1.04) for low, 0.49 (95% CI 0.32 to 0.76) for moderate, 0.46 (95% CI 0.30 to 0.71) for high and 0.50 (95% CI 0.29 to 0.85) for very high consumers. A negative association was found in women, with p values above 0.05 in all categories. Conclusions: Alcohol intake in men aged 29–69 years was associated with a more than 30% lower CHD incidence. This study is based on a large prospective cohort study and is free of the abstainer error. Yes |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=od______2636::2ca6efb024dab169b8f18519771513d1Test https://hdl.handle.net/10668/316Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.od......2636..2ca6efb024dab169b8f18519771513d1 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |