Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes
| العنوان: | Association of TCF7L2 variation with single islet autoantibody expression in children with type 1 diabetes |
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| المؤلفون: | Michael L. Metzker, Jesse Muniz, Ashok Balasubramanyam, Christiane S. Hampe, Luisa M. Rodriguez, Struan F.A. Grant, Dinakar Iyer, Maria J. Redondo, Morey W. Haymond, Fariba Vaziri-Sani |
| المصدر: | BMJ open diabetes research & care; 2(1), pp 000008-000008 (2014) BMJ Open Diabetes Research & Care |
| بيانات النشر: | BMJ Publishing Group, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | medicine.medical_specialty, endocrine system, endocrine system diseases, Transcription Factor, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Endocrinology and Diabetes, medicine.disease_cause, Autoimmunity, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Medicine, 030304 developmental biology, Autoantibodies, 0303 health sciences, Type 1 diabetes, geography, geography.geographical_feature_category, business.industry, Autoantibody, nutritional and metabolic diseases, Genetics/Genomes/Proteomics/Metabolomics, Pediatric Type 1 Diabetes, medicine.disease, Islet, 3. Good health, Endocrinology, Zinc Transporter 8, Immunology, business, TCF7L2, LADA (Latent Autoimmune Diabetes in Adults) |
| الوصف: | Background The transcription factor 7-like 2 (TCF7L2) gene has the strongest genetic association with type 2 diabetes. TCF7L2 also associates with latent autoimmune diabetes in adults, which often presents with a single islet autoantibody, but not with classical type 1 diabetes. Methods We aimed to test if TCF7L2 is associated with single islet autoantibody expression in pediatric type 1 diabetes. We studied 71 prospectively recruited children who had newly diagnosed type 1 diabetes and evidence of islet autoimmunity, that is, expressed ≥1 islet autoantibody to insulin, glutamic acid decarboxylase 65, islet cell autoantigen 512, or zinc transporter 8. TCF7L2 rs7903146 alleles were identified. Data at diagnosis were cross-sectionally analyzed. Results We found that 21.1% of the children with autoimmune type 1 diabetes expressed a single islet autoantibody. The distribution of TCF7L2 rs7903146 genotypes in children with a single autoantibody (n=15) was 40% CC, 26.7% CT and 33.3% TT, compared with children with ≥2 islet autoantibodies (50% CC, 42.9% CT and 7.1% TT, p=0.024). Furthermore, compared with children with ≥2 autoantibodies, single-autoantibody children had characteristics reflecting milder autoimmune destruction of β-cells. Restricting to lean children (body mass index |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2052-4897 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4822819119794aca4fa199810b3cc6Test https://lup.lub.lu.se/record/4913206Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3b4822819119794aca4fa199810b3cc6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20524897 |
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