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1دورية أكاديمية
المؤلفون: Anupam Kharbanda, Kelly R Bergmann, Ling Zhong, Dave Watson, Petter Bjornstad, M Jennifer Abuzzahab, Elizabeth Collins-Dippel, Amanda Nickel
المصدر: BMJ Open, Vol 14, Iss 6 (2024)
مصطلحات موضوعية: Medicine
الوصف: Introduction Approximately 40% of children with diabetic ketoacidosis (DKA) develop acute kidney injury (AKI), which increases the risk of chronic kidney damage. At present, there is limited knowledge of racial or ethnic differences in diabetes-related kidney injury in children with diabetes. Understanding whether such differences exist will provide a foundation for addressing disparities in diabetes care that may continue into adulthood. Further, it is currently unclear which children are at risk to develop worsening or sustained DKA-related AKI. The primary aim is to determine whether race and ethnicity are associated with DKA-related AKI. The secondary aim is to determine factors associated with sustained AKI in children with DKA.Methods and analysis This retrospective, multicentre, cross-sectional study of children with type 1 or type 2 diabetes with DKA will be conducted through the Paediatric Emergency Medicine Collaborative Research Committee. Children aged 2–18 years who were treated in a participating emergency department between 1 January 2020 and 31 December 2023 will be included. Children with non-ketotic hyperglycaemic-hyperosmolar state or who were transferred from an outside facility will be excluded. The relevant predictor is race and ethnicity. The primary outcome is the presence of AKI, defined by Kidney Disease: Improving Global Outcomes criteria. The secondary outcome is ‘sustained’ AKI, defined as having AKI ≥48 hours, unresolved AKI at last creatinine measurement or need for renal replacement therapy. Statistical inference of the associations between predictors (ie, race and ethnicity) and outcomes (ie, AKI and sustained AKI) will use random effects regression models, accounting for hospital variation and clustering.Ethics and dissemination The Institutional Review Board of Children’s Minnesota approved this study. 12 additional sites have obtained institutional review board approval, and all sites will obtain local approval prior to participation. Results will be presented at local or national conferences and for publication in peer-reviewed journals.
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Nguyen Van Vinh Chau, Pham Quang Thai, Marc Choisy, Nguyen Thi Le Thanh, Fuhan Yang, Joseph L Servadio, Ha Minh Lam, Tran Thi Nhu Thao, Nguyen Ha Thao Vy, Huynh Thi Phuong, Tran Dang Nguyen, Dong Thi Hoai Tam, Ephraim M Hanks, Ha Vinh, Ottar N Bjornstad, Maciej F Boni
المصدر: BMJ Global Health, Vol 8, Iss 11 (2023)
مصطلحات موضوعية: Medicine (General), R5-920, Infectious and parasitic diseases, RC109-216
الوصف: Introduction It is well known that influenza and other respiratory viruses are wintertime-seasonal in temperate regions. However, respiratory disease seasonality in the tropics is less well understood. In this study, we aimed to characterise the seasonality of influenza-like illness (ILI) and influenza virus in Ho Chi Minh City, Vietnam.Methods We monitored the daily number of ILI patients in 89 outpatient clinics from January 2010 to December 2019. We collected nasal swabs and tested for influenza from a subset of clinics from May 2012 to December 2019. We used spectral analysis to describe the periodic signals in the system. We evaluated the contribution of these periodic signals to predicting ILI and influenza patterns through lognormal and gamma hurdle models.Results During 10 years of community surveillance, 66 799 ILI reports were collected covering 2.9 million patient visits; 2604 nasal swabs were collected, 559 of which were PCR-positive for influenza virus. Both annual and nonannual cycles were detected in the ILI time series, with the annual cycle showing 8.9% lower ILI activity (95% CI 8.8% to 9.0%) from February 24 to May 15. Nonannual cycles had substantial explanatory power for ILI trends (ΔAIC=183) compared with all annual covariates (ΔAIC=263) in lognormal regression. Near-annual signals were observed for PCR-confirmed influenza but were not consistent over time or across influenza (sub)types. The explanatory power of climate factors for ILI and influenza virus trends was weak.Conclusion Our study reveals a unique pattern of respiratory disease dynamics in a tropical setting influenced by both annual and nonannual drivers, with influenza dynamics showing near-annual periodicities. Timing of vaccination campaigns and hospital capacity planning may require a complex forecasting approach.
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Bjornstad, P G, Michalsen, H
المصدر: British Heart Journal; Mar1974, Vol. 36 Issue 3, p302-306, 5p
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4دورية أكاديمية
المؤلفون: Vashti Berry, Stuart Logan, Mark Tarrant, Aleksandra Borek, Kath Wilkinson, Jenny Lloyd, Gretchen Bjornstad, Beth Cuffe-Fuller, Mary Fredlund, Annabel McDonald, Siobhan Mitchell, Annette Gillett
المصدر: BMJ Open, Vol 11, Iss 8 (2021)
مصطلحات موضوعية: Medicine
وصف الملف: electronic resource
النص الكامل