Biomarkers of chondrosarcoma
| العنوان: | Biomarkers of chondrosarcoma |
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| المؤلفون: | Wonju Jeong, Ha-Jeong Kim |
| المصدر: | Journal of Clinical Pathology |
| بيانات النشر: | BMJ Publishing Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, musculoskeletal diseases, medicine.medical_specialty, animal structures, Angiogenesis, diagnosis, medicine.medical_treatment, Biopsy, Chondrosarcoma, Bone Neoplasms, Review, Malignancy, Pathology and Forensic Medicine, Diagnosis, Differential, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, tumour markers, Predictive Value of Tests, Internal medicine, medicine, Enchondroma, Biomarkers, Tumor, Humans, Neoplasm Staging, business.industry, Cancer, General Medicine, medicine.disease, musculoskeletal system, Immunohistochemistry, Vascular endothelial growth factor, Radiation therapy, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, embryonic structures, Differential diagnosis, Neoplasm Grading, business, bone tumours |
| الوصف: | Clinical outcome prediction is major concern to patients with cancer. Various molecular markers in various carcinomas have been identified in the past few decades. However, accurate predictors in chondrosarcoma have not been developed, even though chondrosarcoma is the second most common primary bone tumour. Chondrosarcoma is the cartilage-forming malignancy and shows a wide spectrum of clinicopathological behaviours. The majority of chondrosarcoma grows slowly and rarely metastasises, and adequate surgery leads to a good prognosis. However, wide surgical excision is acquired in high-grade chondrosarcoma, because this tumour is highly resistant to chemotherapy and radiotherapy. To decide best therapy, accurate diagnostic markers are also necessary in chondrosarcoma. It is reported that angiogenesis and lymphangiogenesis increase by chondrosarcoma staging, and they are promoted by leptin and adiponectin. Several microRNAs to regulate vascular endothelial growth factor (VEGF)-A and VEGF-C are also reported. Alpha-methylacyl-CoA racemase and periostin are proposed as new biomarkers for differential diagnosis of enchondroma and chondrosarcoma. This review summarises that chondrosarcoma diagnostic markers are currently reported. |
| اللغة: | English |
| تدمد: | 1472-4146 0021-9746 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d27031d2d99955d62f66d7499ff1d26Test http://europepmc.org/articles/PMC6204964Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5d27031d2d99955d62f66d7499ff1d26 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14724146 00219746 |
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