المؤلفون: Ghane, Nejla¹, Kattah, Jorge C.^1,2 kattahj@uic.edu, Mannett, Brady¹, Sang H. Hong³

المصدر: Practical Neurology. Feb2024, Vol. 24 Issue 1, p1-5. 5p.

مصطلحات موضوعية: *TYPE 1 diabetes, *GLAUCOMA, *VISION disorders, *IMMUNOSUPPRESSIVE agents, *INTRACRANIAL hypertension, *CATARACT surgery, *OPHTHALMOLOGY, *DRUG approval, *GRAVES' disease, *DIPLOPIA, *GLUCOCORTICOIDS

الشركة/الكيان: UNITED States. Food & Drug Administration

المؤلفون: Cuthbert, Joseph James, Soyiri, Ireneous, Lomax, Stephanie Jayne, Turgoose, John, Fuat, Ahmet, Cohen, Judith, Clark, Andrew L.

المصدر: Heart; Jun2024, Vol. 110 Issue 12, p854-862, 124p

مصطلحات موضوعية: HEART failure, MELAS syndrome, TYPE 1 diabetes, MATURITY onset diabetes of the young, TYPE 2 diabetes, DIAGNOSIS, CARDIOVASCULAR diseases

المؤلفون: Miao-Zhen Qiu, Do-Youn Oh, Kato, Ken, Arkenau, Tobias, Tabernero, Josep, Correa, Marcia Cruz, Zimina, Anastasia V., Bai, Yuxian, Shi, Jianhua, Keun-Wook Lee, Rui-Hua Xu

المصدر: BMJ: British Medical Journal; 6/8/2024, Vol. 385 Issue 8431, p1-11, 13p

مصطلحات موضوعية: ADENOCARCINOMA, STOMACH tumors, PATIENT safety, RESEARCH funding, ANTINEOPLASTIC agents, STATISTICAL sampling, BLIND experiment, PROGRAMMED death-ligand 1, ESOPHAGEAL tumors, TREATMENT effectiveness, RANDOMIZED controlled trials, DESCRIPTIVE statistics, MONOCLONAL antibodies, CANCER chemotherapy, METASTASIS, DRUG efficacy, COMPARATIVE studies, CONFIDENCE intervals, EPIDERMAL growth factor receptors, OVERALL survival, PHARMACODYNAMICS

مصطلحات جغرافية: NORTH America, ASIA, EUROPE

المؤلفون: Lopez-Doriga Ruiz, Paz, Tapia, German, Bakken, Inger J., Håberg, Siri E., Gulseth, Hanne L., Skrivarhaug, Torild, Joner, Geir, Stene, Lars C.

المصدر: Journal of Epidemiology & Community Health; May2024, Vol. 78 Issue 5, p319-325, 7p

مصطلحات موضوعية: TYPE 1 diabetes, PARENTS, RISK assessment, FATHERHOOD, RESEARCH funding, SOCIOECONOMIC factors, PARENTING, DESCRIPTIVE statistics, LONGITUDINAL method, ODDS ratio, MOTHERHOOD, CONFIDENCE intervals, DATA analysis software, SOCIAL classes, EDUCATIONAL attainment, EMPLOYMENT, DISEASE risk factors, CHILDREN

مصطلحات جغرافية: NORWAY

المؤلفون: Subramanian, Savitha, Khan, Farah, Hirsch, Irl B.

المصدر: BMJ: British Medical Journal; 4/20/2024, Vol. 385 Issue 8425, p1-19, 19p

مصطلحات موضوعية: INSULIN therapy, TYPE 1 diabetes, GLUCAGON-like peptide-1 agonists, GLYCOSYLATED hemoglobin, PANCREATIC beta cells, INSULIN, PATIENT care, INSULIN pumps, CONTINUOUS glucose monitoring, MEDICAL research, SODIUM-glucose cotransporter 2 inhibitors, AUTOMATION, GENETICS, BIOMARKERS, DIABETES, HYPOGLYCEMIA

المؤلفون: Lulu Rong, Hongying Zhao, Yunlong Li, Mulan Jin, Jun Lu

المصدر: Journal of Clinical Pathology; Apr2024, Vol. 77 Issue 4, p233-238, 8p

مصطلحات موضوعية: T cells, GENE expression, GENE amplification, SQUAMOUS cell carcinoma, PROGRAMMED death-ligand 1, DNA mismatch repair

المؤلفون: Noske, Aurelia, Steiger, Katja, Ballke, Simone, Kiechle, Marion, Oettler, Dirk, Roth, Wilfried, Weichert, Wilko

المصدر: Journal of Clinical Pathology; Apr2024, Vol. 77 Issue 4, p239-245, 7p

مصطلحات موضوعية: TRIPLE-negative breast cancer, BREAST biopsy, BREAST, PROGESTERONE receptors, PROGRAMMED death-ligand 1, COHEN'S kappa coefficient (Statistics)

المؤلفون: Wookjin Yang, Soon Auck Hong, Jeong-Min Kim, Hae-Bong Jeong, Taek-Kyun Nam, Hyun Ho Choi, Suh Min Kim, Kwang-Yeol Park, Hye Ryoun Kim

المصدر: Journal of NeuroInterventional Surgery; Apr2024, Vol. 16 Issue 4, p352-358, 7p

مصطلحات موضوعية: RISK assessment, CEREBRAL embolism & thrombosis, ACADEMIC medical centers, RECEIVER operating characteristic curves, RESEARCH funding, PROGRAMMED death-ligand 1, CYTOCHEMISTRY, DESCRIPTIVE statistics, SEVERITY of illness index, CLINICAL pathology, KAPLAN-Meier estimator, GENE expression, HISTONES, ISCHEMIC stroke, DISEASE relapse, CEREBRAL infarction, STROKE patients, THROMBECTOMY, CONFIDENCE intervals, VASCULAR diseases, PHENOTYPES, PROPORTIONAL hazards models, BLOOD, DISEASE risk factors, DISEASE complications

مصطلحات جغرافية: SOUTH Korea

مستخلص: Background Thrombi retrieved from patients with acute ischemic stroke may contain prognostic information. Objective: To investigate the relationship between the immunologic phenotype of thrombi and future vascular events in patients with a stroke. Methods This study included patients with acute ischemic stroke who underwent endovascular thrombectomy at Chung-Ang University Hospital in Seoul, Korea, between February 2017 and January 2020. Laboratory and histological variables were compared between patients with and without recurrent vascular events (RVEs). Kaplan-Meier analysis followed by the Cox proportional hazards model was used to identify factors related to RVE. Receiver operating characteristic (ROC) analysis was conducted to evaluate the performance of the immunologic score by combining immunohistochemical phenotypes to predict RVE. Results A total of 46 patients were included in the study with 13 RVEs (mean±SD age, 72.8±11.3 years; 26 (56.5%) men). Thrombi with a lower percentage of programmed death ligand-1 expression (HR=11.64; 95% CI 1.60 to 84.82) and a higher number of citrullinated histone H3 positive cells (HR=4.19; 95% CI 0.81 to 21.75) were associated with RVE. The presence of high-mobility group box 1 positive cell was associated with reduced risk of RVE, but the association was lost after adjustment for stroke severity. The immunologic score, which consists of the three immunohistochemical phenotypes, showed good performance in predicting RVE (area under the ROC curve, 0.858; 95% CI 0.758 to 0.958). Conclusions The immunological phenotype of thrombi could provide prognostic information after stroke. [ABSTRACT FROM AUTHOR]

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المؤلفون: Gosney, John R., Peake, Michael D., Kerr, Keith M.

المصدر: Journal of Clinical Pathology; Feb2024, Vol. 77 Issue 2, p135-139, 5p

مصطلحات موضوعية: NON-small-cell lung carcinoma, TARGETED drug delivery, PROGRAMMED death-ligand 1, SMALL cell lung cancer

المؤلفون: Haragan, Alexander, Parashar, Piya, Bury, Danielle, Cross, Gregory, Gosney, John R.

المصدر: Journal of Clinical Pathology; Feb2024, Vol. 77 Issue 2, p140-144, 5p

مصطلحات موضوعية: MACHINE learning, NON-small-cell lung carcinoma, IMAGE analysis, SMALL cell lung cancer, PROGRAMMED death-ligand 1, FORENSIC pathology