التفاصيل البيبلوغرافية
| العنوان: |
Prospective, multicentre study of external ventricular drainage-related infections in the UK and Ireland. |
| المؤلفون: |
Jamjoom, Aimun A. B., Joannides, Alexis J., Tin-Chung Poon, Michael, Chari, Aswin, Zaben, Malik, Abdulla, Mutwakil A. H., Roach, Joy, Glancz, Laurence J., Solth, Anna, Duddy, John, Brennan, Paul M., Bayston, Roger, Bulters, Diederik O., Mallucci, Conor L., Jenkinson, Michael D., Gray, William P., Kandasamy, Jothy, Hutchinson, Peter J., Kolias, Angelos G., Ahmed, Aminul I. |
| المصدر: |
Journal of Neurology, Neurosurgery & Psychiatry; Feb2018, Vol. 89 Issue 2, p120-126, 7p |
| مصطلحات موضوعية: |
CEREBRAL ventricles, SURGICAL site infections, SURGICAL drainage, CEREBROSPINAL fluid, STAPHYLOCOCCUS epidermidis, PUBLIC health, SURGERY |
| مصطلحات جغرافية: |
UNITED Kingdom, IRELAND |
| مستخلص: |
Objectives: External ventricular drain (EVD) insertion is a common neurosurgical procedure. EVD-related infection (ERI) is a major complication that can lead to morbidity and mortality. In this study, we aimed to establish a national ERI rate in the UK and Ireland and determine key factors influencing the infection risk.Methods: A prospective multicentre cohort study of EVD insertions in 21 neurosurgical units was performed over 6 months. The primary outcome measure was 30-day ERI. A Cox regression model was used for multivariate analysis to calculate HR.Results: A total of 495 EVD catheters were inserted into 452 patients with EVDs remaining in situ for 4700 days (median 8 days; IQR 4-13). Of the catheters inserted, 188 (38%) were antibiotic-impregnated, 161 (32.5%) were plain and 146 (29.5%) were silver-bearing. A total of 46 ERIs occurred giving an infection risk of 9.3%. Cox regression analysis demonstrated that factors independently associated with increased infection risk included duration of EVD placement for ≥8 days (HR=2.47 (1.12-5.45); p=0.03), regular sampling (daily sampling (HR=4.73 (1.28-17.42), p=0.02) and alternate day sampling (HR=5.28 (2.25-12.38); p<0.01). There was no association between catheter type or tunnelling distance and ERI.Conclusions: In the UK and Ireland, the ERI rate was 9.3% during the study period. The study demonstrated that EVDs left in situ for ≥8 days and those sampled more frequently were associated with a higher risk of infection. Importantly, the study showed no significant difference in ERI risk between different catheter types. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Neurology, Neurosurgery & Psychiatry is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
