التفاصيل البيبلوغرافية
| العنوان: |
The immunologic phenotype of thrombi is associated with future vascular events after cerebral infarction. |
| المؤلفون: |
Wookjin Yang, Soon Auck Hong, Jeong-Min Kim, Hae-Bong Jeong, Taek-Kyun Nam, Hyun Ho Choi, Suh Min Kim, Kwang-Yeol Park, Hye Ryoun Kim |
| المصدر: |
Journal of NeuroInterventional Surgery; Apr2024, Vol. 16 Issue 4, p352-358, 7p |
| مصطلحات موضوعية: |
RISK assessment, CEREBRAL embolism & thrombosis, ACADEMIC medical centers, RECEIVER operating characteristic curves, RESEARCH funding, PROGRAMMED death-ligand 1, CYTOCHEMISTRY, DESCRIPTIVE statistics, SEVERITY of illness index, CLINICAL pathology, KAPLAN-Meier estimator, GENE expression, HISTONES, ISCHEMIC stroke, DISEASE relapse, CEREBRAL infarction, STROKE patients, THROMBECTOMY, CONFIDENCE intervals, VASCULAR diseases, PHENOTYPES, PROPORTIONAL hazards models, BLOOD, DISEASE risk factors, DISEASE complications |
| مصطلحات جغرافية: |
SOUTH Korea |
| مستخلص: |
Background Thrombi retrieved from patients with acute ischemic stroke may contain prognostic information. Objective: To investigate the relationship between the immunologic phenotype of thrombi and future vascular events in patients with a stroke. Methods This study included patients with acute ischemic stroke who underwent endovascular thrombectomy at Chung-Ang University Hospital in Seoul, Korea, between February 2017 and January 2020. Laboratory and histological variables were compared between patients with and without recurrent vascular events (RVEs). Kaplan-Meier analysis followed by the Cox proportional hazards model was used to identify factors related to RVE. Receiver operating characteristic (ROC) analysis was conducted to evaluate the performance of the immunologic score by combining immunohistochemical phenotypes to predict RVE. Results A total of 46 patients were included in the study with 13 RVEs (mean±SD age, 72.8±11.3 years; 26 (56.5%) men). Thrombi with a lower percentage of programmed death ligand-1 expression (HR=11.64; 95% CI 1.60 to 84.82) and a higher number of citrullinated histone H3 positive cells (HR=4.19; 95% CI 0.81 to 21.75) were associated with RVE. The presence of high-mobility group box 1 positive cell was associated with reduced risk of RVE, but the association was lost after adjustment for stroke severity. The immunologic score, which consists of the three immunohistochemical phenotypes, showed good performance in predicting RVE (area under the ROC curve, 0.858; 95% CI 0.758 to 0.958). Conclusions The immunological phenotype of thrombi could provide prognostic information after stroke. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
