التفاصيل البيبلوغرافية
| العنوان: |
Attenuation of bleomycin induced pulmonary fibrosis in mice using the heme oxygenase inhibitor Zn-deuteroporphyrin IX-2,4-bisethylene glycol. |
| المؤلفون: |
Atzori L, Chua F, Dunsmore S E, Willis D, Barbarisi M, McAnulty R J, Laurent G J, Atzori, L, Chua, F, Dunsmore, S E, Willis, D, Barbarisi, M, McAnulty, R J, Laurent, G J |
| المصدر: |
Thorax; Mar2004, Vol. 59 Issue 3, p217-223, 7p, 7 Graphs |
| مصطلحات موضوعية: |
IMMUNOSUPPRESSIVE agents, POLYCYCLIC compounds, TETRAPYRROLES, CARBON monoxide, TRANSFORMING growth factors, PORPHYRINS, ANIMAL experimentation, ANTIMETABOLITES, ANTINEOPLASTIC agents, BILIRUBIN, BLEOMYCIN, BODY fluids, COMPARATIVE studies, GLUTATHIONE, GROWTH factors, LACTATE dehydrogenase, LEUCOCYTES, RESEARCH methodology, MEDICAL cooperation, MICE, OXIDOREDUCTASES, PULMONARY fibrosis, RESEARCH, MALONDIALDEHYDE, EVALUATION research, CHEMICAL inhibitors, PREVENTION, THERAPEUTICS |
| مستخلص: |
Background: Pulmonary fibrosis is associated with a poor prognosis. The pathogenesis of fibrotic lung disorders remains unclear, but the extent of tissue damage due to the persistent presence of oxidants or proteases is believed to be important. The heme degrading enzyme heme oxygenase (HO) has been found to be expressed in experimental fibrosis, and generation of free iron and carbon monoxide (CO) by HO has been implicated in oxidant induced lung damage. A study was undertaken to examine the effects of the HO inhibitor Zn-deuteroporphyrin-IX-2,4-bisethylene glycol (Zndtp) on the development of pulmonary fibrosis in the bleomycin model of lung injury and repair.Methods: Zndtp (10 micro mol/kg) was administered subcutaneously twice daily to mice 1 week following the intratracheal instillation of 0.025 U bleomycin. Animals were killed 10 or 21 days after bleomycin instillation and indices of lung damage and fibrosis were evaluated.Results: Bleomycin treatment induced pulmonary cytotoxicity, increased levels of active transforming growth factor beta (TGF-beta), enhanced lung collagen accumulation, and decreased glutathione content. Zndtp administration significantly attenuated these indices.Conclusions: Administration of Zndtp in the bleomycin model resulted in appreciable alveolar cytoprotection and amelioration of pulmonary fibrosis. This molecule and its analogues may warrant further consideration in the treatment of acute lung injury and fibrotic lung disorders. [ABSTRACT FROM AUTHOR] |
|
Copyright of Thorax is the property of BMJ Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
