المؤلفون: Antonia Demleitner, Paul Lingor, Katharina Götze, Benno Ikenberg, Thomas Thiele, Georg Mößmer, Benedikt Wiestler

المصدر: Stroke and Vascular Neurology
Stroke and Vascular Neurology, Vol, Iss

مصطلحات موضوعية: medicine.medical_specialty, COVID-19 Vaccines, blood platelets, Case Report, complication, Argatroban, Sinus Thrombosis, Intracranial, ChAdOx1 nCoV-19, Medicine, Humans, Platelet, Platelet activation, Cerebral venous sinus thrombosis, RC346-429, Pathological, Sinus (anatomy), business.industry, SARS-CoV-2, Vaccination, COVID-19, medicine.disease, Magnetic Resonance Imaging, ddc, medicine.anatomical_structure, Female, Neurology. Diseases of the nervous system, Neurology (clinical), Radiology, haemorrhage, Cardiology and Cardiovascular Medicine, business, Complication, medicine.drug, MRI

الوصف: Vaccine-induced immune thrombotic thrombocytopenia (VITT) and cerebral venous sinus thrombosis (CVST) have been recently described as rare complications following vaccination against SARS-CoV-2 with vector vaccines. We report a case of a young woman who presented with VITT and cerebral CVST 7 days following vaccination with ChAdOx1 nCov-19 (AstraZeneca). While the initial MRI was considered void of pathological findings, MRI 3 days later revealed extensive CVST of the transversal and sigmoidal sinus with intracerebral haemorrhage. Diagnostic tests including a platelet-factor-4-induced platelet activation assay confirmed the diagnosis of VITT. Treatment with intravenous immunoglobulins and argatroban resulted in a normalisation of platelet counts and remission of CVST.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0559778e42cb8630e63615220a8dfba8Test
http://europepmc.org/articles/PMC8717801Test

المؤلفون: Abhay Kumar, Raghunandan Prasad, Ravi Banthia, Hira Lal

المصدر: BMJ Case Rep

مصطلحات موضوعية: Adult, Intracranial Arteriovenous Malformations, Male, medicine.medical_specialty, Case Report, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, Arteriovenous Malformations, 03 medical and health sciences, 0302 clinical medicine, Aneurysm, medicine, Humans, Hematuria, medicine.diagnostic_test, business.industry, Interventional radiology, Intracranial Aneurysm, General Medicine, Digital subtraction angiography, Enbucrilate, medicine.disease, Embolization, Therapeutic, medicine.anatomical_structure, Angiography, cardiovascular system, Lipiodol, Abdomen, Radiology, Renal vein, business, Congenital renal arteriovenous malformation, medicine.drug

الوصف: We report a case of renal arteriovenous malformation (AVM) and describe its angioarchitecture and endovascular management. A 28-year-old male patient presented with visible painless haematuria. CT of the abdomen showed a right renal AVM. Digital subtraction angiography of the right renal vessels showed an AVM of middle and lower pole segmental arteries with communication to a large saccular aneurysm, which was arising from the right main renal vein. Complete occlusion of the AVM was done by using glue (a mixture of n-butyl-cyanoacrylate and lipiodol), resulting in nonvisualisation of the aneurysm on angiography. His vital signs were stable during the procedure. Follow-up CT after 12 months showed no residual flow in the aneurysm, normal upper pole renal parenchyma and nonvisualisation of AVM. Early diagnosis of this clinical entity is of paramount importance for proper management as it can cause massive blood loss and rapid clinical deterioration.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6331a1bc6b180ffab0d4c74f93a760Test
https://europepmc.org/articles/PMC8074538Test/

المؤلفون: Jian Zhang, Anding Xu, Xin Wang, Kangning Chen, Dapeng Mo, Zhongrong Miao, Yuming Xu, Benyan Luo, Bin Peng, Yong Huo, Jizong Zhao, Wei Wang, Shuo Wang, Chen Wang, Linong Ji, Shizheng Wu, Yi Yang, Junbo Ge, Xunming Ji, Tong Zhang, Tielin Li, Ning Wang, Peng Xie, Yun Xu, Jinsheng Zeng, Chaodong Zhang, Zhuo Zhang, Gang Zhao, Yuhua Fan, Jian Yu, Hongbing Chen, Jiangang Duan, Wenhao Zhu, Fubing Ouyang, Yicong Chen, Linfang Lan, Li Guo, Li He, Xiaoyuan Niu, Dingfeng Su, Beisha Tang

المصدر: Stroke and Vascular Neurology
Stroke and Vascular Neurology, Vol 5, Iss 2 (2020)

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, China, Consensus, brain, Clinical Decision-Making, MEDLINE, 030204 cardiovascular system & hematology, Guidelines, lcsh:RC346-429, Brain Ischemia, Decision Support Techniques, Time-to-Treatment, 03 medical and health sciences, Sinus Thrombosis, Intracranial, 0302 clinical medicine, vein, Predictive Value of Tests, Risk Factors, medicine, Humans, Cerebral venous sinus thrombosis, Vein, Stroke, lcsh:Neurology. Diseases of the nervous system, Evidence-Based Medicine, business.industry, Incidence (epidemiology), Warfarin, Guideline, Evidence-based medicine, medicine.disease, medicine.anatomical_structure, Treatment Outcome, Neurology, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, medicine.drug, MRI

الوصف: AimCerebral venous sinus thrombosis (CVST) is a less common cerebrovascular disease that predominantly affects young patients. The incidence of CVST is 2–5/10 000 000/year, accounting for 0.5%–1% of all stroke. To reduce mortality and morbidity associated with CVST, Chinese Stroke Association commissioned the authors to write the current guideline on the management of CVST.MethodsPubMed (MEDLINE), CNKI and Wanfang database were searched for studies related to CVST from 1 January 1990 to 31 July 2019. Data were synthesised by evidence tables. Each recommendation was fully discussed by the writing group members and reviewed by Chinese Stroke Association Stroke Fellow Committees. Levels of evidence grading algorithm of Chinese Stroke Association was used to grade each recommendation.ResultsThis guideline mainly focuses on the diagnostic evaluation, therapeutic strategies and secondary prevention of CVST. CT/CTV and MRI/MRV are recommended in the initial imaging evaluation of patients with suspected CVST. Anticoagulation therapy with low-molecular weight heparin should be initiated in patients with CVST immediately. After the acute stage, warfarin is recommended for 3–6 months to prevent the recurrence of CVST and other venous thromboembolic events.ConclusionsThe guideline summarises the current evidence regarding the management of CVST, and provides references for diagnosis, treatment and secondary prevention of CVST in China.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56524a07c1ad3776e9eca374bfd64b08Test
http://europepmc.org/articles/PMC7337369Test

المؤلفون: Kenta Ochiai, Kazutaka Nishiyama

المصدر: BMJ Case Rep

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Images In…, Linear fracture, Computed tomography, Primary care, 030105 genetics & heredity, 03 medical and health sciences, Sinus Thrombosis, Intracranial, 0302 clinical medicine, medicine, Craniocerebral Trauma, Humans, Medical history, Sinus (anatomy), medicine.diagnostic_test, business.industry, Occipital bone, General Medicine, medicine.disease, Thrombosis, Surgery, Cerebral Sinus, medicine.anatomical_structure, business, human activities, 030217 neurology & neurosurgery

الوصف: A 4-year-old girl with no medical history ran into the road and collided with a car. She was knocked over and injured the back of her head. Her consciousness was clear but she vomited twice. CT scan of the head revealed a linear fracture of the occipital bone across the sinus with no intracranial

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1422f8d6a800e0757052fcb92197f2Test
https://europepmc.org/articles/PMC7852938Test/

المؤلفون: Serafeim N Antonakis, D A H Laidlaw, Mark A P Fajgenbaum, Luke Membrey

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Morning glory disc anomaly, genetic structures, Intracranial Pressure, Valsalva Maneuver, medicine.medical_treatment, Optic Disk, Optic disk, Unusual Association of Diseases/Symptoms, Serous Retinal Detachment, 03 medical and health sciences, 0302 clinical medicine, Ophthalmology, medicine, Valsalva maneuver, Humans, Intracranial pressure, Retina, business.industry, Retinal Detachment, Retinal detachment, General Medicine, medicine.disease, eye diseases, medicine.anatomical_structure, 030228 respiratory system, Cough, 030221 ophthalmology & optometry, sense organs, business, Optic disc

الوصف: We present a case in which a large, bullous, predominantly inferior, serous retinal detachment developed acutely after the Valsalva manoeuvre (from a coughing fit) in an eye with morning glory disc anomaly. We postulate that a rapid alteration in intracranial pressure was transmitted through the cavitary disc defect. This allowed a sudden influx of cerebrospinal fluid and/or liquefied vitreous into the subretinal space. This previously unreported case provides important evidence for the role of intracranial pressure fluctuations in the pathogenesis of macular schisis and neurosensory detachment secondary to optic disc cavitations.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6551f2050ec281ce091a113ee03d646aTest
https://europepmc.org/articles/PMC5786901Test/

المؤلفون: Ruth Denton-Beaumont, Katherine L. Hull

المصدر: BMJ Case Rep

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, medicine.medical_treatment, Suicide, Attempted, 030105 genetics & heredity, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Intracranial foreign body, Medicine, Head Injuries, Penetrating, Humans, Medical unit, Incidental Findings, Rehabilitation, Unexpected Outcome (Positive or Negative) Including Adverse Drug Reactions, Suicide attempt, business.industry, Psychiatric assessment, Brain, General Medicine, Middle Aged, Foreign Bodies, Surgery, medicine.anatomical_structure, Brain Injuries, Nail (anatomy), Nail gun, Presentation (obstetrics), business, Tomography, X-Ray Computed, 030217 neurology & neurosurgery

الوصف: A 54-year-old man was referred to the acute medical unit with a suspected stroke after presenting to his general practitioner with altered speech, left sided facial droop and confusion. The patient had a new right sided swelling on the lateral aspect of his head but did not report any history of trauma. Imaging revealed a 9.2 cm nail entering via the right parietal bone with associated acute haemorrhage. After further discussion with the patient, he disclosed a suicide attempt with a nail gun 5 days prior to presentation. The nail was successfully removed by the neurosurgical team and the patient received rehabilitation and psychiatric assessment on the brain injury unit before going home.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33070fb5ccae0f6c2224b3e7ebbf30f6Test
https://europepmc.org/articles/PMC6663196Test/

المؤلفون: Prasad Ellanti, Tom McCarthy, Nuala McAuley, Andrew Moriarity

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Intracranial Pressure, Radiography, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, Pneumocephalus, Skull fracture, medicine, Humans, Glasgow Coma Scale, 030212 general & internal medicine, Intracranial pressure, Cerebrospinal fluid leak, Cerebrospinal Fluid Leak, Skull Fractures, business.industry, General Medicine, medicine.disease, Skull, medicine.anatomical_structure, Radiology, business

الوصف: A 35-year-old man presented to the emergency department, with loss of consciousness subsequent to a fall off a wall of six-foot height. He struck his right occipital area against a short metal spike and was noted to have a small scalp laceration with a discharge of clear fluid consistent with cerebrospinal fluid (CSF). His Glasgow Coma Score (GCS) was 15 on admission. A plain film radiograph of his skull demonstrated pockets of air (figure 1) and an emergent CT scan demonstrated significant pneumocephaly (figure 2A, C, E, G) …

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79e75c880c4e183eb5b84fe95328647Test
https://europepmc.org/articles/PMC4746527Test/

المؤلفون: Marios C. Papadopoulos, Samira Saadoun, Suliang Chen

مصطلحات موضوعية: Adult, Mean arterial pressure, medicine.medical_specialty, Traumatic brain injury, Blood Pressure, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Intensive care, Pressure, medicine, Humans, Arterial Pressure, 030212 general & internal medicine, Cerebral perfusion pressure, Spinal Cord Injuries, Aged, Monitoring, Physiologic, Intracranial pressure, business.industry, Disease Management, Recovery of Function, Middle Aged, Prognosis, medicine.disease, Spinal cord, United Kingdom, Surgery, Psychiatry and Mental health, medicine.anatomical_structure, Spinal Cord, Regional Blood Flow, Spinal Injuries, Anesthesia, Multivariate Analysis, Neurology (clinical), Neurosurgery, business, 030217 neurology & neurosurgery, Cohort study

الوصف: In the UK, blood pressure management after acute, severe traumatic spinal cord injury (TSCI) is variable.1 The American Association of Neurological Surgeons (AANS) recommends maintaining mean arterial pressure (MAP) at 85–95 mm Hg for a week after injury, but with little supporting evidence.2 To rationalise blood pressure management, we monitored intraspinal pressure (ISP) and spinal cord perfusion pressure (SCPP=MAP−ISP) from the injury site.3 Our technique is safe4 and analogous to monitoring intracranial pressure (ICP) and cerebral perfusion pressure (CPP) in traumatic brain injury (TBI). The data indicate that, after TSCI, ISP rises and SCPP falls.3 Here we show strong correlation between high ISP or low SCPP and reduced neurological recovery. Our findings raise the possibility that interventions to reduce ISP or increase SCPP after TSCI may improve neurological outcome. ### Patient recruitment Approval for this observational cohort study was granted by the National Research Ethics Service London–St Giles Committee. Inclusion criteria are: (1) Severe TSCI defined as American spinal injuries association Impairment Scale (AIS) grade A, B or C; (2) Age 18–70 years; (3) Timing between TSCI and surgery within 72 hours. Exclusion criteria are: (1) Patients unable to consent; (2) Other major injuries or comorbidities; (3) Penetrating TSCI. Surgery and early management took place at St. George's Hospital. Consent was obtained by each patient. ### Surgery Following bony realignment and posterior fixation, the ISP probe (Codman, Depuy Synthes, Leeds, UK) was tunnelled through …

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df1a3ad4b879a6fec7d4a15543e3438Test
https://openaccess.sgul.ac.uk/id/eprint/108415/1/deleteme.pdfTest

المؤلفون: Uday S Limaye, Prabath Kumar Mondel, Rashmi Saraf

مصطلحات موضوعية: Adult, Intracranial Arteriovenous Malformations, Male, medicine.medical_specialty, endocrine system, Fistula, Arteriovenous fistula, Article, Temporal lobe, Tinnitus, Medicine, Humans, Vertebral Artery, medicine.diagnostic_test, business.industry, Angiography, Digital Subtraction, Arteriovenous malformation, Ultrasonography, Doppler, General Medicine, Digital subtraction angiography, Anatomy, Cerebral Arteries, medicine.disease, Cerebral Veins, Temporal Lobe, medicine.anatomical_structure, Angiography, Arteriovenous Fistula, cardiovascular system, Pia Mater, Radiology, business, Carotid Artery, Internal, Rete mirabile, Artery

الوصف: A rete mirabile is a vascular network of intercommunicating small arteries or arterioles that replace the definitive adult artery supplying the brain. It supplies the brain in lower mammals but is not seen in normal human embryological development. A 26-year-old man presented with worsening tinnitus that was interfering with his sleep. On CT and digital subtraction angiography he was found to have a temporal lobe pial arteriovenous fistula with bilateral carotid and vertebral rete mirabile. The patient was offered open surgical and endovascular treatment options for pial arteriovenous fistula but he refused both and opted for conservative medical management. At 6-month follow-up he continued to have pulsatile tinnitus but was otherwise neurologically normal. We present the first described association of rete mirabile with pial arteriovenous fistula and discuss its clinical presentation and imaging features, with a review of the literature for bilateral carotid and vertebral rete mirabile.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a204fd96e9c23acb6901a0a1b20da461Test
https://europepmc.org/articles/PMC5318614Test/

المؤلفون: Akhila Kumar Panda

مصطلحات موضوعية: medicine.medical_specialty, Intracranial Tuberculoma, Foot drop, Neurology, business.industry, Motor Cortex, Sensory loss, General Medicine, medicine.disease, Article, Surgery, medicine.anatomical_structure, Tuberculoma, Intracranial, Radicular pain, medicine, Vomiting, Humans, Right lower limb, Female, medicine.symptom, business, Child, Peroneal Neuropathies, Motor cortex

الوصف: A 9-year-old girl presented with one episode of focal short lasting nocturnal seizure without impaired consciousness involving right lower limb that persisted for 1 min. This event was neglected by the patient and brought attention on retrospective analysis. There was no history of fever, headache, vomiting, visual blurring or altered sensorium. Twenty days later, she developed foot drop in her right leg which led to problems with walking. There was no history of trauma, hypopigmented patch, sensory loss or radicular pain. Cranial nerve examinations were normal including fundi. Tone was normal in all limbs except …

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381f054ce51d101afcbe7894720416acTest
https://europepmc.org/articles/PMC3736241Test/