التفاصيل البيبلوغرافية
| العنوان: |
Helicobacter pylori antigen stool test(HpSA) and [sup 13]C-urea breath test(UBT) in patients after eradicating treatments. |
| المؤلفون: |
Perri, F., Manes, G., Nardone, G., Neri, M., Vaira, D. |
| المصدر: |
Gut; Sep2002 Supplement 2, Vol. 51, pA105, 1/4p |
| مصطلحات موضوعية: |
TREATMENT of helicobacter pylori infections, BACTERIAL diseases |
| مصطلحات جغرافية: |
UNITED States |
| مستخلص: |
Background: Current guidelines recommend either UBT or HpSA for monitoring Hp infection. Aim of this multi-center study was to evaluate the agreement between the two tests in patients after treatment. Methods: After 4-6 weeks eradication regimen, patients were tested with both UBT (75mg [sup 13]C-urea) and HpSA (Meridian Diagnostics USA). Cut-off values (DOB30) for UBT were positive (> 5‰), indeterminate (3.01-4.99‰), and negative (0.160). Cut-off values (OD-450nm) for HpSA test were positive (> 0.160), indeterminate (0.159-0.140), and negative (< 0.140). Patients with either discordant or indeterminate tests were re-endoscoped with multiple biopsies for RUT, culture, histology, and immunohistochemistry to semiquantitatively assess the ratio between the coccoid and bacillary forms (C/B) of Hp in gastric mucosa. Patients were considered still infected if at least two of the biopsy-based tests were positive and successfully eradicated if all four tests were negative. Results: 458 patients (46±14 years) were enrolled: 422 (92.2%) had concordant UBT and HpSA (352 negative and 70 positive), 2 (0.4%) indeterminate (1 on UBT and 1 on HpSA), and 34 (7.4%) discordant tests. 28 patients (26 with discordant and 2 with indeterminate tests) underwent endoscopy: the HpSA was inaccurate in 24 cases (19 false negative, 4 false positive, and 1 indeterminate results) while the UBT was inaccurate in 4 (2 false positive, 1 false negative, and 1 indeterminate results). Biopsy-based tests showed no bacillary or coccoid forms in all 5 endoscoped patients, who were negative on UBT and positive on HpSA, but in one in whom the C/B ratio was 3/1 in both antrum and corpus. Conclusions: UBT and HpSA tests give discordant or indeterminate results in 8% of patients after eradicating treatments. When compared to biopsy-based "gold standard" tests, the HpSA test is less accurate than the UBT. Coccoid forms are not the cause of false positive results on HpSA tests. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
