P166 Effects of low-vs high-dose fluticasone/formoterol combination therapy on AMP challenge in asthmatic patients
| العنوان: | P166 Effects of low-vs high-dose fluticasone/formoterol combination therapy on AMP challenge in asthmatic patients |
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| المؤلفون: | M Lomax, Zuzana Diamant, Meena Jain, F Kanniess |
| المصدر: | Thorax. 68:A150.3-A151 |
| بيانات النشر: | BMJ, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, medicine.medical_specialty, Combination therapy, business.industry, Inhaler, Urology, medicine.disease, Crossover study, Fluticasone propionate, Anesthesia, Medicine, Asthmatic patient, Formoterol Fumarate, Fluticasone-formoterol, business, Asthma, medicine.drug |
| الوصف: | Background The ICS fluticasone propionate (FP) and the LABA formoterol fumarate (FORM) have now been combined in a single aerosol inhaler (FP/FORM; flutiform ® ). The effect of low- (2 puffs 50/5 µg bid) vs high-dose (2 puffs 250/10 µg bid) FP/FORM on airway responsiveness to AMP was compared in an incomplete block, placebo-controlled, 2-way crossover study. Post hoc data analysis from patients who received both FP/FORM doses is presented. Methods 62 patients (33M, 29F; =18yrs; reversible FEV 1 =60% pred.) discontinued maintenance ICS medication for 2 - 3wks; those showing a provocative dose of AMP producing a 20% decline in FEV 1 (AMP PD 20 FEV 1 ) of 20 FEV 1 (day 1 vs day 28) between treatments were compared by an ANCOVA. Results 15 patients were randomised to receive both high- and low-dose FP/FORM. The change in AMP PD 20 FEV 1 was greater with FP/FORM high- compared with low-dose (LS means: high dose = 11 mg; 95% CI 4.3, 27.9; low dose = 4.6 mg, 95% CI 1.8, 11.8), with a statistically significant 2.4 fold difference in AMP PD 20 FEV 1 (1.2 doubling doses) between doses (LS mean: 2.4; 95% CI 1.3, 4.5; p = 0.012). FP/FORM was well-tolerated; only few (mild or moderate) AEs occurred. Conclusions A significant dose-response was found between low- and high-dose FP/FORM with the higher dose demonstrating a greater reduction in airway responsiveness to AMP. |
| تدمد: | 1468-3296 0040-6376 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::d35ff92bcb274db2e41693a0d6b02be7Test https://doi.org/10.1136/thoraxjnl-2013-204457.317Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi...........d35ff92bcb274db2e41693a0d6b02be7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14683296 00406376 |
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