التفاصيل البيبلوغرافية
| العنوان: |
Predictive risk factors of acute kidney injury after cytoreductive surgery and cisplatin-based hyperthermic intra-peritoneal chemotherapy for ovarian peritoneal carcinomatosis |
| المؤلفون: |
Angeles, Martina Aida, Quenet, François, Vieille, Pierre, Gladieff, Laurence, Ruiz, Jean, Picard, Muriel, Migliorelli, Federico, Chaltiel, Leonor, Martínez-Gómez, Carlos, Martinez, Alejandra, Ferron, Gwénaël |
| المصدر: |
International Journal of Gynecologic Cancer ; volume 29, issue 2, page 382-391 ; ISSN 1048-891X 1525-1438 |
| بيانات النشر: |
BMJ |
| سنة النشر: |
2019 |
| الوصف: |
Objective The aim of our study was to assess the incidence and identify the predictive risk factors of acute kidney injury after cytoreductive surgery and cisplatin-based hyperthermic intra-peritoneal chemotherapy. Methods This is a retrospective study from two centers evaluating patients with advanced or recurrent ovarian cancer who underwent cytoreductive surgery followed by cisplatin-based hyperthermic intra-peritoneal chemotherapy from January 2007 to December 2013. Patients were classified into two groups according to the occurrence of acute kidney injury, defined as a glomerular filtration rate at post-operative day 7 25% lower than at day 0. We also evaluated acute kidney injury following Risk, Injury, Failure, Lost and End-stage kidney function criteria. Univariate and multivariate analyses were conducted in order to assess the association between different variables and the occurrence of acute kidney injury. Results Sixty-six patients were included: 29 (44%) underwent first-line treatment and 37 (56%) were treated for recurrent disease. The incidence of post-operative acute kidney injury was 48%. After multivariate analysis, hypertension (OR 18.6; 95% CI 1.9 to 182.3; p=0.012) and low intra-operative diuresis (OR 0.5; 95% CI 0.4 to 0.8; p=0.001) were associated with acute kidney injury. Conclusion The incidence of acute kidney injury after cytoreductive surgery and cisplatin-based hyperthermic intra-peritoneal chemotherapy was high. Hypertension and low intra-operative diuresis were independent risk factors for this complication. Adequate peri-operative hydration, in order to maintain correct diuresis, could decrease the occurrence of acute kidney injury in patients undergoing cytoreductive surgery plus hyperthermic intra-peritoneal chemotherapy. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1136/ijgc-2018-000099 |
| الإتاحة: |
https://doi.org/10.1136/ijgc-2018-000099Test |
| رقم الانضمام: |
edsbas.62AF2709 |
| قاعدة البيانات: |
BASE |
