التفاصيل البيبلوغرافية
| العنوان: |
Rheumatoid arthritis and changes on spirometry by smoking status in two prospective longitudinal cohorts |
| المؤلفون: |
Hayashi, Keigo, McDermott, Gregory C, Juge, Pierre-Antoine, Moll, Matthew, Cho, Michael H, Wang, Xiaosong, Paudel, Misti L, Doyle, Tracy J, Kinney, Gregory L, Sansone-Poe, Danielle, Young, Kendra, Dellaripa, Paul F, Wallace, Zachary S, Regan, Elizabeth A, Hunninghake, Gary M, Silverman, Edwin K, Ash, Samuel Y, San Jose Estepar, Raul, Washko, George R, Sparks, Jeffrey A |
| المساهمون: |
National Institutes of Health, NHLBI, National Institutes of Health/National Heart, Lung, and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, COPD Foundation |
| المصدر: |
RMD Open ; volume 10, issue 2, page e004281 ; ISSN 2056-5933 |
| بيانات النشر: |
BMJ |
| سنة النشر: |
2024 |
| الوصف: |
Objective To compare longitudinal changes in spirometric measures between patients with rheumatoid arthritis (RA) and non-RA comparators. Methods We analysed longitudinal data from two prospective cohorts: the UK Biobank and COPDGene. Spirometry was conducted at baseline and a second visit after 5–7 years. RA was identified based on self-report and disease-modifying antirheumatic drug use; non-RA comparators reported neither. The primary outcomes were annual changes in the per cent-predicted forced expiratory volume in 1 s (FEV 1 %) and per cent predicted forced vital capacity (FVC%). Statistical comparisons were performed using multivariable linear regression. The analysis was stratified based on baseline smoking status and the presence of obstructive pattern (FEV 1 /FVC <0.7). Results Among participants who underwent baseline and follow-up spirometry, we identified 233 patients with RA and 37 735 non-RA comparators. Among never-smoking participants without an obstructive pattern, RA was significantly associated with more FEV 1 % decline (β=−0.49, p=0.04). However, in ever smokers with ≥10 pack-years, those with RA exhibited significantly less FEV 1 % decline than non-RA comparators (β=0.50, p=0.02). This difference was more pronounced among those with an obstructive pattern at baseline (β=1.12, p=0.01). Results were similar for FEV 1 /FVC decline. No difference was observed in the annual FVC% change in RA versus non-RA. Conclusions Smokers with RA, especially those with baseline obstructive spirometric patterns, experienced lower FEV 1 % and FEV 1 /FVC decline than non-RA comparators. Conversely, never smokers with RA had more FEV 1 % decline than non-RA comparators. Future studies should investigate potential treatments and the pathogenesis of obstructive lung diseases in smokers with RA. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1136/rmdopen-2024-004281 |
| الإتاحة: |
https://doi.org/10.1136/rmdopen-2024-004281Test |
| حقوق: |
http://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: |
edsbas.8AE1E0F |
| قاعدة البيانات: |
BASE |
