التفاصيل البيبلوغرافية
| العنوان: |
Brain abscess in children, a two-centre audit: outcomes and controversies |
| المؤلفون: |
Gilard, Vianney, Beccaria, Kévin, Hartley, John C, Blanot, Stéphane, Marqué, Sophie, Bourgeois, Marie, Puget, Stephanie, Thompson, Dominic, Zerah, Michel, Tisdall, Martin |
| المصدر: |
Archives of Disease in Childhood ; volume 105, issue 3, page 288-291 ; ISSN 0003-9888 1468-2044 |
| بيانات النشر: |
BMJ |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
Pediatrics, Perinatology and Child Health |
| الوصف: |
Objective The aim of this study was to better characterise clinical presentation, management and outcome in infants and children with brain abscess. Methods The authors conducted a retrospective, multicentre study in two national reference centres over a 25-year period (1992–2017). During this period, 116 children and 28 infants (age <1 year) with brain abscess were treated. Results The median age at diagnosis was 101.5 (range: 13–213) months in children and 1 (0–11) month in infants. Significant differences were observed between children and infants. The most common predisposing factor was meningitis in infants (64% of cases vs 3% in children), while it was otolaryngology-related infection in children (31% of cases vs 3.6% in infants). Infants presented more frequently with fever and meningism compared with children. 115 patients were treated with aspiration and 11 with excision. Reoperation was required in 29 children vs 1 infant. The overall mortality rate was 4% (3.4% for children, 7.1% for infants). At 3-month follow-up, the outcome was favourable in 86% of children vs in 68% of infants. Conclusion There is a clear difference between children and infants with brain abscess in terms of predisposing factors, causative organisms and outcome. Despite surgical drainage and directed antibiotic therapy, 25% of patients with brain abscess require reoperation. Mortality is improved compared with historical series; however, long-term morbidity is significant particularly in the infant population. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1136/archdischild-2018-316730 |
| الإتاحة: |
https://doi.org/10.1136/archdischild-2018-316730Test |
| رقم الانضمام: |
edsbas.5CA39DDE |
| قاعدة البيانات: |
BASE |
